Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Optical coherence tomography-derived lipid core burden index and clinical outcomes: results from the CLIMA registry.

Author information

Affiliations

  • 1. Centro per la Lotta Contro L'Infarto - CLI Foundation, Rome, Italy.
      Authors
    • Biccirè FG 1, 8
    • Budassi S 1
    • Marco V 1
    • Paoletti G 1
    • Debelak C 1
    • Sammartini E 1
    • Prati F 1
    (7 authors)
  • 2. Department of Cardiology, Fujita Health University Hospital, Toyoake, Japan.
      Authors
    • Ozaki Y 2
    (1 author)
  • 3. Interventional Cardiology Unit, Ospedale Brotzu, Cagliari, Italy.
      Authors
    • Boi A 3
    (1 author)
  • 4. Departement of Cardiovascular and Thoracic Sciences, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
      Authors
    • Romagnoli E 4
    • Burzotta F 4
    • Crea F 4
    (3 authors)
  • 5. Cardiology Department, Santa Maria Goretti Hospital, Latina, Italy.
      Authors
    • Di Pietro R 5
    • Versaci F 5
    (2 authors)
    • Show all (9)

ORCIDs linked to this article

Show all (8)

European Heart journal. Cardiovascular Imaging, 01 Mar 2023, 24(4):437-445
https://doi.org/10.1093/ehjci/jeac110 PMID: 35718858 

Abstract 

Aims

The aim of this study was to assess the morphological characteristics and prognostic implications of the optical coherence tomography (OCT)-derived lipid core burden index (LCBI).

Methods and results

OCT-LCBI was assessed in 1003 patients with 1-year follow-up from the CLIMA multicentre registry using a validated software able to automatically obtain a maximum OCT-LCBI in 4 mm (maxOCT-LCBI4mm). Primary composite clinical endpoint included cardiac death, myocardial infarction, and target-vessel revascularization. A secondary analysis using clinical outcomes of CLIMA study was performed. Patients with a maxOCT-LCBI4mm ≥ 400 showed higher prevalence of fibrous cap thickness (FCT) <75 μm [odds ratio (OR) 1.43, 95% confidence interval (CI) 1.03-1.99; P = 0.034], lipid pool arc >180° (OR 3.93, 95%CI 2.97-5.21; P < 0.001), minimum lumen area <3.5 mm2 (OR 1.5, 95%CI 1.16-1.94; P = 0.002), macrophage infiltration (OR 2.38, 95%CI 1.81-3.13; P < 0.001), and intra-plaque intimal vasculature (OR 1.34, 95%CI 1.05-1.72; P = 0.021). A maxOCT-LCBI4mm ≥400 predicted the primary endpoint [adjusted hazard ratio (HR) 1.86, 95%CI 1.1-3.2; P = 0.019] as well as the CLIMA endpoint (HR 2.56, 95%CI 1.24-5.29; P = 0.011). Patients with high lipid content and thin FCT < 75 µm were at higher risk for adverse events (HR 4.88, 95%CI 2.44-9.72; P < 0.001).

Conclusions

A high maxOCT-LCBI4mm was related to poor outcome and vulnerable plaque features. This study represents a step further in the automated assessment of the coronary plaque risk profile.

Full text links 

Read article at publisher's site: https://doi.org/10.1093/ehjci/jeac110

Citations & impact 

Impact metrics

7
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (7) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

Centro per la Lotta contro l'Infarto - Fondazione Onlus

    Centro per la Lotta contro l’Infarto – Fondazione Onlus