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Natural history of circulating miRNAs in Duchenne disease: Association with muscle injury and metabolic parameters.

Author information

Affiliations

  • 1. Laboratorio de Nutrición Molecular, Unidad de Investigación Médica en Nutrición, Unidad Médica de Alta Especialidad Hospital de Pediatría "Dr. Silvestre Frenk Freund, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Mexico City (CDMX), Mexico.
      Authors
    • Almeida-Becerril T 1
    • Rodríguez-Cruz M 1
    • Hernández-Cruz SY 1
    (3 authors)
  • 2. Departamento de Genética, Unidad Médica de Alta Especialidad Hospital General "Dr. Gaudencio González Garza", Centro Médico Nacional La Raza, IMSS, CDMX, Mexico.
      Authors
    • Ruiz-Cruz ED 2
    • Mendoza CRS 2
    (2 authors)
  • 3. Departamento de Genética Médica, Hospital de Pediatría "Dr. Silvestre Frenk Freund", CMN-Siglo XXI, IMSS, CDMX, Mexico.
      Authors
    • Cárdenas-Conejo A 3
    (1 author)
  • 4. Servicio de Electrodiagnóstico y Distrofia Muscular, Instituto Nacional de Rehabilitación, CDMX, Mexico.
      Authors
    • Escobar-Cedillo RE 4
    (1 author)
  • 5. Lung Diseases Laboratory 12, Biomedicine Research Unit (UBIMED), Facultad de Estudios Superiores Iztacala, UNAM, Tlalnepantla de Baz, Estado de México, Mexico.
      Authors
    • Ávila-Moreno F 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

Acta Neurologica Scandinavica, 24 Aug 2022, 146(5):512-524
https://doi.org/10.1111/ane.13673 PMID: 36000352 

Abstract 

Objectives

This study aimed to evaluate whether the expression of circulating dystromiRs and a group of oxidative stress-related (OS-R) miRNAs is associated with muscle injury and circulating metabolic parameters in Duchenne muscular dystrophy (DMD) patients.

Methods

Twenty-four DMD patients were included in this cross-sectional study. Clinical scales to evaluate muscle injury (Vignos, GMFCS, Brooke, and Medical Research Council), enzymatic muscle injury parameters (CPK, ALT, and AST), anthropometry, metabolic indicators, physical activity, serum dystromiRs (miR-1-3p, miR-133a-3p, and miR-206), and OS-R miRNAs (miR-21-5p, miR-31-5p, miR-128-3p, and miR-144-3p) levels were measured in ambulatory and non-ambulatory DMD patients.

Results

DystromiRs (except miR-1-3p) and miRNAs OS-R levels were lower (p-value <.05) in the non-ambulatory group than the ambulatory group. The expression of those miRNAs correlated with Vignos scale score (For instance, rho = -0.567, p-value <0.05 for miR-21-5p) and with other scales scores of muscle function and strength. CPK, AST, and ALT concentration correlated with expression of all miRNAs (For instance, rho = 0.741, p-value <.05 between miR-206 level and AST concentration). MiR-21-5p level correlated with glucose concentration (rho = -0.369, p-value = .038), and the miR-1-3p level correlated with insulin concentration (rho = 0.343, p-value = .05).

Conclusions

Non-ambulatory DMD patients have lower circulating dystromiRs and OS-R miRNAs levels than ambulatory DMD patients. The progressive muscle injury is associated with a decrease in the expression of those miRNAs, evidencing DMD progress. These findings add new information about the natural history of DMD.

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Read article at publisher's site: https://doi.org/10.1111/ane.13673

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Funding 

Funders who supported this work.

Fondo de Investigación en Salud del Instituto Mexicano del Seguro Social (1)