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Chemical constituents from the roots of Zanthoxylum bungeanum Maxim. and their neuroprotective activities.

Author information

Affiliations

  • 1. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China; University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Beijing 100049, China.
      Authors
    • Ma LM 1
    • Wang K 1
    (2 authors)
  • 2. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China.
      Authors
    • Wang CB 2
    • Sang CY 2
    • Yang JL 2
    (3 authors)
  • 3. College of Chemical Engineering, Northwest Minzu University, Lanzhou 730030, China.
      Authors
    • Zhai XX 3
    (1 author)
  • 4. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, China; Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai 264000, China.
      Authors
    • Wang WF 4
    (1 author)
  • 5. Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai 264000, China.
      Authors
    • Wang J 5
    (1 author)

Fitoterapia, 17 Oct 2022, 163:105337
https://doi.org/10.1016/j.fitote.2022.105337 PMID: 36265759 

Abstract 

Twenty-two isolates, including two previously undescribed compounds identified as benzoyltembamide (1) and P-benzoyphenethyl anisate (21), were isolated and identified from a methanol extract of the roots of Zanthoxylum bungeanum Maxim. (Rutaceae) using diverse chromatographic materials and pre-HPLC. Their structures were elucidated on the basis of spectroscopic and spectrometric data analysis such as HR-ESI-MS, 1D and 2D NMR, IR and UV, as well as single-crystal X-ray diffraction for crystalline compounds. All the compounds (except for compound 16) were isolated from the roots of Z. bungeanum for the first time. Selected compounds were evaluated for their antioxidant activities. Compound 18 attenuated the H2O2-induced cytotoxicity and blocked the accumulation of ROS in SH-SY5Y cells, and exhibited potent neuroprotective activity.

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Read article at publisher's site: https://doi.org/10.1016/j.fitote.2022.105337

Read article for free, from open access legal sources, via Unpaywall: http://manuscript.elsevier.com/S0367326X22002155/pdf/S0367326X22002155.pdfUnpaywall

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