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De novo genome assembly and analyses of 12 founder inbred lines provide insights into maize heterosis.

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Affiliations

  • 1. Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.
      Authors
    • Wang B 1
    • Hou M 1, 8
    • Li X 1
    • Li C 1
    • Zhao B 1
    • Xu H 1
    • Bai Z 1
    • Xia Z 1
    • Wang H 1
    (9 authors)
  • 2. State Key Laboratory of Plant Physiology and Biochemistry & National Maize Improvement Center, Department of Plant Genetics and Breeding, China Agricultural University, Beijing, China.
      Authors
    • Shi J 2
    • Lai J 2
    (2 authors)
  • 3. College of Agronomy and National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou, China.
      Authors
    • Ku L 3
    • Yao W 3
    • Hou G 3
    • Chen Y 3
    (4 authors)
  • 4. Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding, Maize Research Center, Beijing Academy of Agriculture & Forestry Sciences, Beijing, China.
      Authors
    • Song W 4
    • Zhang R 4
    • Li C 4
    • Sun X 4
    • Wang S 4
    • Zhao J 4
    (6 authors)
  • 5. Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China.
      Authors
    • Li C 5
    • Li Y 5
    • Wang T 5
    (3 authors)
    • Show all (10)

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Nature Genetics, 16 Jan 2023, 55(2):312-323
https://doi.org/10.1038/s41588-022-01283-w PMID: 36646891 

This article has been corrected. See Nat Genet. 2023 Feb 2;:.

Abstract 

Hybrid maize displays superior heterosis and contributes over 30% of total worldwide cereal production. However, the molecular mechanisms of heterosis remain obscure. Here we show that structural variants (SVs) between the parental lines have a predominant role underpinning maize heterosis. De novo assembly and analyses of 12 maize founder inbred lines (FILs) reveal abundant genetic variations among these FILs and, through expression quantitative trait loci and association analyses, we identify several SVs contributing to genomic and phenotypic differentiations of various heterotic groups. Using a set of 91 diallel-cross F1 hybrids, we found strong positive correlations between better-parent heterosis of the F1 hybrids and the numbers of SVs between the parental lines, providing concrete genomic support for a prevalent role of genetic complementation underlying heterosis. Further, we document evidence that SVs in both ZAR1 and ZmACO2 contribute to yield heterosis in an overdominance fashion. Our results should promote genomics-based breeding of hybrid maize.

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Read article at publisher's site: https://doi.org/10.1038/s41588-022-01283-w

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