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Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices.

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Affiliations

  • 1. Department of of Internal Medicine and Iowa Institute of Human Genetics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA; VA Medical Center, Iowa City, Iowa, USA.
      Authors
    • Thomas CP 1
    (1 author)
  • 2. Division of Nephrology, Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
      Authors
    • Daloul R 2
    (1 author)
  • 3. Saint Louis University Transplant Center, SSM Health Saint Louis University Hospital, St. Louis, Missouri, USA.
      Authors
    • Lentine KL 3
    • Caliskan Y 3
    (2 authors)
  • 4. Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
      Authors
    • Gohh R 4
    (1 author)
  • 5. Mid-Carolinas Transplant Center, Medical University of South Carolina, Lancaster, South Carolina, USA.
      Authors
    • Anand PM 5
    (1 author)
    • Show all (12)

ORCIDs linked to this article

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American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 01 Mar 2023, 23(5):597-607
https://doi.org/10.1016/j.ajt.2023.02.020 PMID: 36868514 

Review

Abstract 

The growing accessibility and falling costs of genetic sequencing techniques has expanded the utilization of genetic testing in clinical practice. For living kidney donation, genetic evaluation has been increasingly used to identify genetic kidney disease in potential candidates, especially in those of younger ages. However, genetic testing on asymptomatic living kidney donors remains fraught with many challenges and uncertainties. Not all transplant practitioners are aware of the limitations of genetic testing, are comfortable with selecting testing methods, comprehending test results, or providing counsel, and many do not have access to a renal genetic counselor or a clinical geneticist. Although genetic testing can be a valuable tool in living kidney donor evaluation, its overall benefit in donor evaluation has not been demonstrated and it can also lead to confusion, inappropriate donor exclusion, or misleading reassurance. Until more published data become available, this practice resource should provide guidance for centers and transplant practitioners on the responsible use of genetic testing in the evaluation of living kidney donor candidates.

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Read article at publisher's site: https://doi.org/10.1016/j.ajt.2023.02.020

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Funding 

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NIDDK NIH HHS (3)