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Alterations induced by Bisphenol A on cellular organelles and potential relevance on human health.

Author information

Affiliations

  • 1. Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
      Authors
    • Khan NG 1
    • Tungekar B 1
    • Adiga D 1
    (3 authors)
  • 2. Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India; Center for DNA Repair and Genome Stability (CDRGS), Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
      Authors
    • Chakrabarty S 2
    • Kabekkodu SP 2
    (2 authors)
  • 3. Department of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
      Authors
    • Rai PS 3
    (1 author)

ORCIDs linked to this article

Biochimica et Biophysica acta. Molecular Cell Research, 05 Jun 2023, 1870(7):119505
https://doi.org/10.1016/j.bbamcr.2023.119505 PMID: 37286138 

Review

Abstract 

Bisphenol A (BPA) is a chemical partially soluble in water and exists in a solid state. Its structural similarity with estrogen makes it an endocrine-disrupting chemical. BPA can disrupt signaling pathways at very low doses and may cause organellar stress. According to in vitro and in vivo studies, BPA interacts with various cell surface receptors to cause organellar stress, producing free radicals, cellular toxicity, structural changes, DNA damage, mitochondrial dysfunction, cytoskeleton remodeling, centriole duplication, and aberrant changes in several cell signaling pathways. The current review summarizes the impact of BPA exposure on the structural and functional aspects of subcellular components of cells such as the nucleus, mitochondria, endoplasmic reticulum, lysosome, ribosome, Golgi apparatus, and microtubules and its consequent impact on human health.

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Read article at publisher's site: https://doi.org/10.1016/j.bbamcr.2023.119505

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Funding 

Funders who supported this work.

Indian Council of Medical Research (1)

Manipal Academy of Higher Education