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The ubiquitin-proteasome system in breast cancer.

Author information

Affiliations

  • 1. Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
      Authors
    • Han D 1
    • Jiang S 1
    (2 authors)
  • 2. Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.
      Authors
    • Wang L 2
    (1 author)
  • 3. Department of Breast Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; Pathology Tissue Bank, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China; Research Institute of Breast Cancer, Shandong University, Jinan, Shandong 250012, China.
      Authors
    • Yang Q 3
    (1 author)

Trends in Molecular Medicine, 14 Jun 2023, 29(8):599-621
https://doi.org/10.1016/j.molmed.2023.05.006 PMID: 37328395 

Review

Abstract 

Ubiquitin-proteasome system (UPS) is a selective proteolytic system that is associated with the expression or function of target proteins and participates in various physiological and pathological processes of breast cancer. Inhibitors targeting the 26S proteasome in combination with other drugs have shown promising therapeutic effects in the clinical treatment of breast cancer. Moreover, several inhibitors/stimulators targeting other UPS components are also effective in preclinical studies, but have not yet been applied in the clinical treatment of breast cancer. Therefore, it is vital to comprehensively understand the functions of ubiquitination in breast cancer and to identify potential tumor promoters or tumor suppressors among UPS family members, with the aim of developing more effective and specific inhibitors/stimulators targeting specific components of this system.

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Read article at publisher's site: https://doi.org/10.1016/j.molmed.2023.05.006

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