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First trimester maternal plasma proteomic changes predictive of spontaneous moderate/late preterm delivery.

Author information

Affiliations

  • 1. Laboratory of Medical Genetics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
      Authors
    • Mavreli D 1
    • Treager-Synodinos J 1
    (2 authors)
  • 2. 1st Department of Obstetrics and Gynecology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
      Authors
    • Theodora M 2
    • Daskalakis G 2
    (2 authors)
  • 3. 1st Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
      Authors
    • Lambrou G 3
    (1 author)
  • 4. Laboratory of Clinical Biochemistry - Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, Athens, Greece.
      Authors
    • Avgeris M 4
    (1 author)
  • 5. 3rd Department of Obstetrics and Gynecology, School of Medicine Athens University, National and Kapodistrian University of Athens, Athens, Greece.
      Authors
    • Papantoniou N 5
    (1 author)
    • Show all (6)

ORCIDs linked to this article

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 01 Dec 2023, 36(2):2232074
https://doi.org/10.1080/14767058.2023.2232074 PMID: 37424082 

Abstract 

Objective

Identification of differentially expressed proteins (DEPs) in first trimester maternal plasma between pregnant women with a subsequent spontaneous moderate/late Preterm Delivery (sPTD) and women who delivered at term. The sPTD group consisted of women who delivered between 32°/7 and 366/7 weeks of gestation.

Methods

Isobaric tags for relative and absolute quantification (iTRAQ) coupled with LC-MS/MS was used for the analysis of five first trimester maternal plasma samples obtained from women with a subsequent moderate/late preterm sPTD and five women with term deliveries. Enzyme-linked immunosorbent assay (ELISA) was further applied in an independent cohort of 29 sPTD cases and 29 controls to verify the expression levels of selected proteins.

Results

236 DEPs, mainly linked to coagulation and complement cascade, were identified in first trimester maternal plasma obtained from the sPTD group. Decreased levels of selected proteins, namely, VCAM-1, SAA, and Talin-1, were further confirmed using ELISA, highlighting their potential as candidate predictive biomarkers for sPTD at32°/7 and 366/7 weeks of gestation.

Conclusion

First trimester maternal plasma proteomic analysis revealed protein changes associated with subsequent moderate/late preterm sPTD.

Full text links 

Read article at publisher's site: https://doi.org/10.1080/14767058.2023.2232074

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