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[Diagnostic Efficacy of 68Ga-Labeled Prostate-Specific Membrane Antigen and 18F-Labeled Sodium Fluoride PET/CT in Prostate Cancer With Bone Metastasis].

Author information

Affiliations

  • 1. Department of Nuclear Medicine,The First People's Hospital of Neijiang,Neijiang,Sichuan 641000,China.
      Authors
    • Wang AB 1
    • Feng LJ 1
    • Ni PP 1
    (3 authors)
  • 2. Department of Nuclear Medicine,Sichuan Provincial People's Hospital,Sichuan Academy of Medical Sciences,Chengdu 610072,China.
      Authors
    • He LM 2
    • Zhang W 2
    (2 authors)
  • 3. Department of Nuclear Medicine,Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China.
      Authors
    • Li HM 3
    (1 author)

Zhongguo yi xue ke xue Yuan xue bao. Acta Academiae Medicinae Sinicae, 01 Aug 2023, 45(4):634-639Language:chi
https://doi.org/10.3881/j.issn.1000-503x.15336 PMID: 37654144 

Abstract 

Objective To compare the efficiency of 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA-11) and 18F-labeled sodium fluoride (18F-NaF) PET/CT in the diagnosis of bone metastasis in the patients with prostate cancer.Methods The prostate cancer patients suspected of bone metastasis who underwent 68Ga-PSMA-11 PET/CT and 18F-NaF PET/CT from January 2018 to January 2021 were included in this study.The number of lesions,maximum standardized uptake value (SUVmax),and tumor-to-background (T/B) ratio were compared between the two methods.Results 18F-NaF PET/CT detected more metastases than 68Ga-PSMA-11 PET/CT (310 vs.264,P<0.001).The median SUVmax[23.2 (16.4,33.4) vs.4.1 (2.5,5.6)] and median T/B ratio[7.0 (4.9,9.9) vs.6.7 (3.7,9.6)] of 18F-NaF PET/CT were higher than those of 68Ga-PSMA-11 PET/CT (all P<0.001).With the number of lesions as the indicator,the sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of 18F-NaF PET/CT were 100.0%,92.0%,92.0%,98.7%,and 100.0% respectively,and those of 68Ga-PSMA-11 PET/CT were 85.2%,94.0%,79.2%,98.9%,and 50.5%,respectively.Conclusion 18F-NaF PET/CT is superior to 68Ga-PSMA-11 PET/CT in the detection of bone metastases of prostate cancer.

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Read article at publisher's site: https://doi.org/10.3881/j.issn.1000-503x.15336

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