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Polyamines and hormesis: Making sense of a dose response dichotomy.

Author information

Affiliations

  • 1. Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA, 01003, USA.
      Authors
    • Calabrese E 1
    (1 author)
  • 2. Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL, USA.
      Authors
    • Hayes AW 2
    (1 author)
  • 3. University of Maine, 5728 Fernald Hall, Room 201, Orono, ME, 04469, USA.
      Authors
    • Pressman P 3
    (1 author)
  • 4. Saint Francis Hospital and Medical Center, Hartford, CT, USA.
      Authors
    • Kapoor R 4
    (1 author)
  • 5. Stantec (ChemRisk), Boston, MA, USA.
      Authors
    • Dhawan G 5
    (1 author)
    • Show all (7)

Chemico-biological Interactions, 08 Oct 2023, 386:110748
https://doi.org/10.1016/j.cbi.2023.110748 PMID: 37816449 

Review

Abstract 

The diverse biological effects of polyamines (putrescine, spermidine and spermine) were reviewed in the context of hormesis in an integrative manner for the first time. The findings illustrate that each of these polyamines commonly induces hormetic dose responses in a wide range of biological models and types of cells for multiple endpoints in numerous plant species and animal models. Plant research emphasized preconditioning experimental studies in which the respective polyamines conferred some protection against the damaging effects of a broad range of environmental stressors such as drought, salinity, cold/heat, heavy metals and UV-damage in an hormetic manner. Polyamine-based animal hormesis studies emphasized biomedical endpoints such as longevity and neuroprotection. These findings have important biological and biomedical implications and should guide experimental designs of low dose investigations.

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Read article at publisher's site: https://doi.org/10.1016/j.cbi.2023.110748

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Funding 

Funders who supported this work.

Air Force Office of Scientific Research

    ExxonMobil Foundation (1)

    U.S. Air Force