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[Association of phthalate and polycyclic aromatic hydrocarbon exposure during early pregnancy with premature delivery: A cohort study].

Author information

Affiliations

  • 1. Research Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
      Authors
    • Chen J 1
    • Ou ZX 1
    • Feng QY 1
    • Peng LQ 1
    • Chen JY 1
    • Xiong F 1
    • Liu CY 1
    • Zhao K 1
    • Zhang HP 1
    • Fang YW 1
    (10 authors)
  • 2. Department of Urology, Jinling Hospital, Nanjing University School of Medicine / General Hospital of Eastern Theater Command, Nanjing, Jiangsu 20002, China.
      Authors
    • Shang XJ 2
    (1 author)

Zhonghua nan ke xue = National Journal of Andrology, 01 Oct 2022, 28(10):873-880Language:chi
PMID: 37838952 

Abstract 

Objective

To explore the relationship of the exposure to phthalate esters (PAE) and polycyclic aromatic hydrocarbons (PAH) with clinical premature delivery during early pregnancy.

Methods

We conducted a baseline questionnaire survey among 821 pregnant women undergoing prenatal examination in Hubei Provincial Maternal and Child Health Care Hospital, collected their morning urine samples and followed them up to the outcomes of pregnancy. We quantitatively analyzed 10 PAE and 10 PAH metabolites in the urine samples, followed by Mann-Whitney U test, chi-square test, and logistic regression analysis.

Results

The detection rate of the 5 factors exposed to was >80% while that of phthalic acid monobenzyl ester (MBzP) was <50% in PAEs; that of the 5 factors exposed to was >80%, that of 3-hydroxyphene (3-OHPHE) was 86.91% while that of 4-hydroxyphene (4-OHPHE) was <50% in PAHs. Logistic regression analysis showed that the risk of premature delivery was higher in the high MBzP- than in the low MBzP-exposure group (aOR = 2.26, 95% CI: 1.17－4.39).

Conclusion

High MBzP-exposure may be a risk factor for premature delivery.

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