Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Effect of Echinacea purpurea (L.) Moench and its extracts on the immunization outcome of avian influenza vaccine in broilers.

Author information

Affiliations

  • 1. College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
      Authors
    • Wang X 1
    • Chan Y 1
    • Li S 1
    • Li M 1
    • Lin F 1
    • Lin R 1
    • Su Y 1
    • Wang C 1
    • Shi D 1
    (9 authors)
  • 2. College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Nanomedicine Center, The GBA National Institute for Nanotechnology Innovation, 136 Kaiyuan Avenue, Guangzhou, 510700, China.
      Authors
    • Chen J 2
    (1 author)
  • 3. Faculty of Veterinary and Animal Science, The Islamia University of Bahawalpur, 63100, Pakistan.
      Authors
    • Mehmood K 3
    (1 author)
  • 4. KBCMA, College of Veterinary and Animal Sciences, Narowal, Pakistan.
      Authors
    • Idrees A 4
    (1 author)

ORCIDs linked to this article

Journal of Ethnopharmacology, 13 Oct 2023, 319(Pt 3):117306
https://doi.org/10.1016/j.jep.2023.117306 PMID: 37839770 

Abstract 

Ethnopharmacological relevance

Echinacea purpurea (L.) Moench (EP) is a perennial herbaceous flowering plant with immunomodulatory effects. However, the immunomodulatory effects of EP on broilers after vaccination are still unclear.

Aim of the study

The aim is to study the effect of EP and Echinacea purpurea (L.) Moench extracts(EE) on avian influenza virus (AIV) immunity, and further explore the potential mechanism of immune regulation.

Materials and methods

Broilers were fed with feed additives containing 2% EP or 0.5% EE, and vaccinated against avian influenza. The samples were collected on the 7th, 21st, and 35th day after vaccination, and the feed conversion ratio (FCR) was calculated. Blood antibody titer, jejunal sIgA content, tight junction protein, gene and protein expression of TLR4-MAPK signaling pathway were also detected.

Results

The results showed that vaccination could cause immune stress, weight loss, increase sIgA content, and up-regulate the expression of tight junction proteins, including zonula occludens-1 (ZO-1), Occludin, and Claudin-1, as well as the genes of Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), receptor-associated factor 6 (TRAF6), activator protein 1 (AP-1) protein gene expression on TLR4-mitogen-activated protein kinase (MAPK) signaling pathway, and the protein expression of MyD88, extracellular regulated protein kinases (ERK), and c-Jun N-terminal kinase (JNK). EP and EE could increase the body weight of broilers, further improve antibody titers, decrease FCR, increase sIgA levels, up-regulate the expression of tight junction proteins, including ZO-1, Occludin, and Claudin-1, as well as the genes of TLR4, MyD88, TRAF6, and AP-1 and the protein expression of MyD88, ERK, and JNK in the TLR4-MAPK signaling pathway.

Conclusion

In conclusion, EP and EE can increase the broiler's production performance and improve vaccine immune effect through the TLR4-MAPK signaling pathway.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.jep.2023.117306

Citations & impact 

This article has not been cited yet.

Impact metrics

Alternative metrics

Altmetric item for https://www.altmetric.com/details/155423821
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/155423821

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

Natural Science Foundation of Guangdong Province (1)