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Epigenetic programming for obesity and noncommunicable disease: From womb to tomb.

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Affiliations

  • 1. Department of Biotechnology, Genetics, and Cellular Biology, State University of Maringá, 5790 Av Colombo, Sala 19, Maringá, PR, 87020-900, Brazil.
      Authors
    • Saavedra LPJ 1
    • Piovan S 1
    • Moreira VM 1
    • Gonçalves GD 1
    • Ferreira ARO 1
    • Ribeiro MVG 1
    • Peres MNC 1
    • Almeida DL 1
    • Raposo SR 1
    • da Silva MC 1
    • Barbosa LF 1
    • de Freitas Mathias PC 1
    (12 authors)

ORCIDs linked to this article

Reviews in Endocrine & Metabolic Disorders, 02 Dec 2023, 25(2):309-324
https://doi.org/10.1007/s11154-023-09854-w PMID: 38040983 

Review

Abstract 

Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as preconception, gestation, lactation and adolescence, and the understanding of factors that influence the risk of an adult individual for developing obesity, metabolic and cardiovascular diseases, is the focus of the DOHaD (Developmental Origins of Health and Disease) research line. In this sense, advancements in molecular biology techniques have contributed significantly to the understanding of the mechanisms underlying the observed phenotypes, their morphological and physiological alterations, having as a main driving factor the epigenetic modifications and their consequent modulation of gene expression. The present narrative review aimed to characterize the different susceptible phases of development and associated epigenetic modifications, and their implication in the development of non-communicable diseases. Additionally, we provide useful insights into interventions during development to counteract or prevent long-term programming for disease susceptibility.

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Read article at publisher's site: https://doi.org/10.1007/s11154-023-09854-w

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Conselho Nacional de Desenvolvimento Científico e Tecnológico

    Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

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