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Epidemiological and clinical evolution of multisystem inflammatory syndrome in children throughout the SARS-CoV-2 pandemic in a tertiary Italian children's hospital.

Author information

Affiliations

  • 1. Pronto Soccorso e Medicina d'Urgenza, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
      Authors
    • Bellini T 1
    • Bustaffa M 1
    • Piccotti E 1
    (3 authors)
  • 2. Terapia Semintensiva, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
      Authors
    • Brisca G 2
    • Moscatelli A 2
    (2 authors)
  • 3. Pediatria e Malattie Infettive, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
      Authors
    • Mariani M 3
    • Castagnola E 3
    (2 authors)
  • 4. Centro Malattie Autoinfiammatorie e Immunodeficienze, Istituto Giannina Gaslini, IRCCS, Genoa, Italy.
      Authors
    • Caorsi R 4
    • Gattorno M 4
    (2 authors)
  • 5. Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantile (DINOGMI), University of genoa, Genoa, Italy.
      Authors
    • Drago E 5
    • Strati MF 5
    (2 authors)

ORCIDs linked to this article

Acta Paediatrica (Oslo, Norway : 1992), 08 Dec 2023, 113(3):523-530
https://doi.org/10.1111/apa.17054 PMID: 38066729 

Abstract 

Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening disease temporally linked to SARS-CoV-2 whose incidence and clinical presentation may have been altered by the different SARS-CoV-2 variants and by vaccination.

Methods

We retrospectively collected the data of all MIS-C cases admitted to the Gaslini Children's Hospital, the hub for SARS-CoV-2 related diseases in Liguria region, Italy, from 01 October 2020, to 30 November 2022, evaluating the ratio between MIS-C cases and (1) COVID-19 paediatric cases in our region, (2) emergency department admissions and (3) emergency department febrile patients. We also compared MIS-C incidence in pre- post-vaccination periods.

Results

We observed a significant global decline in the incidence of MIS-Cover the four variant periods and after the starting of vaccination whereas clinical features, therapeutic management and severity did not significantly vary.

Conclusions

In our setting, we demonstrated a significant decrease of MIS-C incidence according to the predominant variant and including not vaccinated children. Regardless of variant type, the patients showed similar phenotypes and severity throughout the pandemic. SARS-CoV-2 variants as well as immune protection after previous infections and/or vaccination may have interacted by playing different roles and reducing the incidence of MIS-C.

Full text links 

Read article at publisher's site: https://doi.org/10.1111/apa.17054

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