Sickle cell anemia and central nervous system infarction: a neuropathological study.

Rothman SM; Fulling KH; Nelson JS

doi:10.1002/ana.410200606

Abstract

CNS infarcts were demonstrated in 12 of 24 autopsied patients with sickle cell anemia. The infarcts occurred most extensively in the territory supplied by the distal branches of the internal carotid artery, especially the anterior-middle cerebral artery boundary zone. They were regularly associated with organizing and recanalizing thrombi involving the distal cervical and proximal intracranial divisions of the internal carotid system. On the basis of these findings, we infer that the pathogenesis of the infarction involves perfusion failure or intraarterial embolization in addition to intravascular sickling.

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References

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Sickle cell anemia and central nervous system infarction: a neuropathological study.

Abstract

Full text links

References

Title not supplied

The effects of systemic hypotension upon the human brain. Clinical and neuropathological observations in 11 cases.

Cholesterol embolism as a cause of transient ischemic attacks and cerebral infarction.

Large cerebral vessel disease in sickle cell anaemia.

Cerebral vascular disease accompanying sickle cell anemia.

The pathogenesis of ischaemic neuronal damage along the cerebral arterial boundary zones in Papio anubis.

AN X-RAY MICROSCOPIC STUDY OF THE VASA VASORUM OF THE INTRACRANIAL ARTERIES.

Intracranial vessels lack vasa vasorum.

Abnormal hemoglobin as a cause of neurologic disease.

Erythrocyte adherence to endothelium in sickle-cell anemia. A possible determinant of disease severity.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment.

From Stress to Sick(le) and Back Again-Oxidative/Antioxidant Mechanisms, Genetic Modulation, and Cerebrovascular Disease in Children with Sickle Cell Anemia.

Impaired post-stroke collateral circulation in sickle cell anemia mice.

Molecular and environmental contributors to neurological complications in sickle cell disease.

Insulin-like Growth Factor-1 Prevents Hypoxia/Reoxygenation-Induced White Matter Injury in Sickle Cell Mice.

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