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Tetracycline and sulfadiazine toxicity in human liver cells Huh-7.

Author information

Affiliations

  • 1. Department of Agricultural Resources and Environment, School of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, China.
      Authors
    • Yao X 1
    • Agathokleous E 1
    • Wei Y 1
    • Feng X 1
    • Li H 1
    • Zhang T 1
    • Li S 1
    • Luo XS 1
    (8 authors)
  • 2. Department of Agricultural Resources and Environment, School of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, China; Academy of Environmental Planning & Design, Co., Ltd, Nanjing University, Nanjing, 210008, China.
      Authors
    • Cheng Z 2
    (1 author)
  • 3. Sri Guru Ram Das (SGRD) University of Health Sciences, Amritsar, India.
      Authors
    • Dhawan G 3
    (1 author)

ORCIDs linked to this article

Environmental Pollution (Barking, Essex : 1987), 27 Jan 2024, 345:123454
https://doi.org/10.1016/j.envpol.2024.123454 PMID: 38286259 

Abstract 

As typical antibiotics, tetracycline (TC) and sulfadiazine (SDZ) enter the human body through the food chain. Therefore, it is necessary to understand their individual and combined toxicity. In this study, the effects of TC, SDZ, and their mixture on cell viability, cell membrane damage, liver cell damage, and oxidative damage were evaluated in in vitro assays with human liver cells Huh-7. The results showed cytotoxicity of TC, SDZ, and their mixture, which induced oxidative stress and caused membrane and cell damage. The effect of antibiotics on Huh-7 cells increased with increasing concentration, except for lactate dehydrogenase (LDH) activity that commonly showed a threshold concentration response and cell viability, which commonly showed a biphasic trend, suggesting the possibility of hormetic responses where proper doses are included. The toxicity of TC was commonly higher than that of SDZ when applied at the same concentration. These findings shed light on the individual and joint effects of these major antibiotics on liver cells, providing a scientific basis for the evaluation of antibiotic toxicity and associated risks.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.envpol.2024.123454

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