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Effect of physical exercise on immune, inflammatory, cardiometabolic biomarkers, and fatty acids of breast cancer survivors: results from the MAMA_MOVE Gaia After Treatment trial.

Author information

Affiliations

  • 1. Medical Oncology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho (CHVNG/E), 4434-502, Vila Nova de Gaia, Portugal.
      Authors
    • Joaquim A 1, 2, 3
    • Amarelo A 1, 3
    • Capela A 1, 3
    (3 authors)
  • 2. Institute of Biomedicine (IBIMED), Department of Medical Sciences, University of Aveiro, 3810-193, Aveiro, Portugal.
      Authors
    • Joaquim A 1, 2, 3
    • Góis A 2
    • Soares A 2
    • Viamonte S 2, 3
    • Helguero LA 2
    (5 authors)
  • 3. ONCOMOVE®-Associação de Investigação de Cuidados de Suporte em Oncologia (AICSO), 4410-406, Vila Nova de Gaia, Portugal.
      Authors
    • Joaquim A 1, 2, 3
    • Garcia C 3
    • Amarelo A 1, 3
    • Antunes P 3
    • Capela A 1, 3
    • Viamonte S 2, 3
    • Alves AJ 3
    (7 authors)
  • 4. Department of Mathematics, University of Aveiro, 3810-193, Aveiro, Portugal.
      Authors
    • Afreixo V 4
    (1 author)
  • 5. Institute of Physiology, Faculty of Medicine of the University of Lisbon and Cardiovascular Centre of the University of Lisbon, 1649-028, Lisbon, Portugal.
      Authors
    • Geraldes V 5
    • Afonso AI 5
    (2 authors)
    • Show all (6)

ORCIDs linked to this article

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Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 21 Feb 2024, 32(3):174
https://doi.org/10.1007/s00520-024-08365-x PMID: 38378875 

Abstract 

Purpose

Physical exercise has positive effects on clinical outcomes of breast cancer survivors such as quality of life, fatigue, anxiety, depression, body mass index, and physical fitness. We aimed to study its impact on immune, inflammatory, cardiometabolic, and fatty acids (FA) biomarkers.

Methods

An exploratory sub-analysis of the MAMA_MOVE Gaia After Treatment trial (NCT04024280, registered July 18, 2019) was performed. Blood sample collections occurred during the control phase and at eight weeks of the intervention phase. Samples were subjected to complete leukocyte counts, cytokine, and cardiometabolic marker evaluation using flow cytometry, enzyme-linked immunoassays, and gas chromatography.

Results

Ninety-three percent of the 15 participants had body mass index ≥ 25 kg/m2. We observed a decrease of the plasmatic saturated FA C20:0 [median difference - 0.08% (p = 0.048); mean difference - 0.1 (95%CI - 0.1, - 0.0)], positively associated with younger ages. A tendency to increase the saturated FA C18:0 and the ratio of unsaturated/saturated FA and a tendency to decrease neutrophils (within the normal range) and interferon-gamma were observed.

Conclusions

Positive trends of physical exercise on circulating immune cells, inflammatory cytokines, and plasmatic FA were observed. Larger studies will further elucidate the implications of physical exercise on metabolism. These exploratory findings may contribute to future hypothesis-driven research and contribute to meta-analyses.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s00520-024-08365-x

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Comissão de Coordenação e Desenvolvimento Regional do Centro (1)

Comissão de Coordenação e Desenvolvimento Regional do Centro (1)

FCT - Fundação para a Ciência e Tecnologia (4)

FCT – Fundação para a Ciência e Tecnologia (4)

Fundo Europeu de Desenvolvimento Regional (1)

Liga Portuguesa Contra o Cancro – Núcleo regional do centro