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The role of cardiac microenvironment in cardiovascular diseases: implications for therapy.

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Affiliations

  • 1. School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China.
      Authors
    • Yao J 1
    • Chen Y 1
    • Huang Y 1
    • Shi X 1
    (4 authors)
  • 2. Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China.
      Authors
    • Sun X 2
    (1 author)

ORCIDs linked to this article

Human Cell, 18 Mar 2024, 37(3):607-624
https://doi.org/10.1007/s13577-024-01052-3 PMID: 38498133 

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Abstract 

Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and atherosclerosis, are the leading causes of death worldwide. The heart is a complicated organ composed of multicellular types, including cardiomyocytes, fibroblasts, endothelial cells, vascular smooth muscle cells, and immune cells. Cellular specialization and complex interplay between different cell types are crucial for the cardiac tissue homeostasis and coordinated function of the heart. Mounting studies have demonstrated that dysfunctional cells and disordered cardiac microenvironment are closely associated with the pathogenesis of various cardiovascular diseases. In this paper, we discuss the composition and the homeostasis of cardiac tissues, and focus on the role of cardiac environment and underlying molecular mechanisms in various cardiovascular diseases. Besides, we elucidate the novel treatment for cardiovascular diseases, including stem cell therapy and targeted therapy. Clarification of these issues may provide novel insights into the prevention and potential targets for cardiovascular diseases.

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Read article at publisher's site: https://doi.org/10.1007/s13577-024-01052-3

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Funding 

Funders who supported this work.

National Natural Science Foundation of China (2)

Natural Science Foundation of Jiangsu Province (1)