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Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non-muscle Invasive Bladder Cancer Prognosis in the Be-Well Study.

Author information

Affiliations

  • 1. Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
      Authors
    • Wang Z 1
    • Pratt R 1
    • Ambrosone CB 1
    • Tang L 1
    (4 authors)
  • 2. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
      Authors
    • Kwan ML 2
    • Lee VS 2
    • Roh JM 2
    • Ergas IJ 2
    • Quesenberry CP 2
    • Kushi LH 2
    (6 authors)
  • 3. Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
      Authors
    • Haque R 3
    • Cannavale KL 3
    (2 authors)
  • 4. Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
      Authors
    • Singh PK 4
    (1 author)
  • 5. Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
      Authors
    • Goniewicz M 5
    (1 author)
    • Show all (8)

ORCIDs linked to this article

Molecular Nutrition & Food Research, 06 Apr 2024, 68(8):e2400087
https://doi.org/10.1002/mnfr.202400087 PMID: 38581346 

Free full text available after 06 Apr 2025

Abstract 

Scope

Dietary isothiocyanate (ITC) exposure from cruciferous vegetable (CV) intake may improve non-muscle invasive bladder cancer (NMIBC) prognosis. This study aims to investigate whether genetic variations in key ITC-metabolizing/functioning genes modify the associations between dietary ITC exposure and NMIBC prognosis outcomes.

Methods and results

In the Bladder Cancer Epidemiology, Wellness, and Lifestyle Study (Be-Well Study), a prospective cohort of 1472 incident NMIBC patients, dietary ITC exposure is assessed by self-reported CV intake and measured in plasma ITC-albumin adducts. Using Cox proportional hazards regression models, stratified by single nucleotide polymorphisms (SNPs) in nine key ITC-metabolizing/functioning genes, it is calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for recurrence and progression. The rs15561 in N-acetyltransferase 1 (NAT1) is alter the association between CV intake and progression risk. Multiple SNPs in nuclear factor E2-related factor 2 (NRF2) and nuclear factor kappa B (NFκB) are modify the associations between plasma ITC-albumin adduct level and progression risk (pint < 0.05). No significant association is observed with recurrence risk. Overall, >80% study participants are present with at least one protective genotype per gene, showing an average 65% reduction in progression risk with high dietary ITC exposure.

Conclusion

Despite that genetic variations in ITC-metabolizing/functioning genes may modify the effect of dietary ITCs on NMIBC prognosis, dietary recommendation of CV consumption may help improve NMIBC survivorship.

Full text links 

Read article at publisher's site: https://doi.org/10.1002/mnfr.202400087

References 

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Funding 

Funders who supported this work.

NCI NIH HHS (9)

National Cancer Institute (5)