Inhibition of prolipoprotein signal peptidase by globomycin.

Dev IK; Harvey RJ; Ray PH

doi:10.1016/s0021-9258(18)88911-6

Abstract

Globomycin inhibits the prolipoprotein-specific signal peptidase activity by binding to the enzyme in a noncompetitive manner (Ki = 36 nM). The Km of prolipoprotein signal peptidase for the prolipoprotein substrate is 6 (+/- 1) microM.

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http://intl.jbc.org/cgi/content/abstract/260/10/5891

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iScience, 27(10):110894, 05 Sep 2024
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Identification and heterologous expression of the globomycin biosynthetic gene cluster.
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii.
Huang KJ, Pantua H, Diao J, Skippington E, Volny M, Sandoval W, Tiku V, Peng Y, Sagolla M, Yan D, Kang J, Katakam AK, Michaelian N, Reichelt M, Tan MW, Austin CD, Xu M, Hanan E, Kapadia SB
Proc Natl Acad Sci U S A, 119(38):e2123117119, 13 Sep 2022
Cited by: 6 articles | PMID: 36099298 | PMCID: PMC9499571
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Breaking down the cell wall: Still an attractive antibacterial strategy.
Zhou J, Cai Y, Liu Y, An H, Deng K, Ashraf MA, Zou L, Wang J
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Inhibition of prolipoprotein signal peptidase by globomycin.

Abstract

Full text links

Citations & impact

Impact metrics

Citations of article over time

Article citations

A screen for cell envelope stress uncovers an inhibitor of prolipoprotein diacylglyceryl transferase, Lgt, in <i>Escherichia</i> <i>coli</i>.

Molecular insights into Escherichia coli Cpx envelope stress response activation by the sensor lipoprotein NlpE.

Identification and heterologous expression of the globomycin biosynthetic gene cluster.

Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii.

Breaking down the cell wall: Still an attractive antibacterial strategy.

Data

Data that cites the article

Protein families in InterPro

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