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Sentinel node mapping, sentinel node mapping plus back-up lymphadenectomy, and lymphadenectomy in Early-sTage cERvical caNcer scheduled for fertilItY-sparing approach: The ETERNITY project.

Collaborators (68)

Author information

Affiliations

  • 1. Gynecologic Oncologic Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.
      Authors
    • Bogani G 1
    • Chiappa V 1
    • Raspagliesi F 1
    • Contributors
      Bogani G 1
    • Contributors
      Chiappa V 1
    • Contributors
      Palladino S 1
    • Contributors
      Raspagliesi F 1
    (7 authors)
  • 2. Gynecologic Oncology Unit, Department of Women, Children and Public Health Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Institute of Obstetrics and Gynecology, Università Cattolica Del Sacro Cuore, Rome, Italy.
      Authors
    • Scambia G 2
    • Fagotti A 2
    • Fanfani F 2
    • Contributors
      Scambia G 2
    • Contributors
      Fagotti A 2
    • Contributors
      Fanfani F 2
    • Contributors
      De Vincenzo R 2
    (7 authors)
  • 3. Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona, Italy.
      Authors
    • Ciavattini A 3
    (1 author)
  • 4. Gynecologic Oncology Unit, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy.
      Authors
    • Sopracordevole F 4
    (1 author)
  • 5. Endoscopica Malzoni, Center for Advanced Endoscopic Gynecological Surgery, Avellino, Italy.
      Authors
    • Malzoni M 5
    (1 author)
    • Show all (12)

ORCIDs linked to this article

Show all (7)

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 08 Jun 2024, 50(9):108467
https://doi.org/10.1016/j.ejso.2024.108467 PMID: 38901291 

Abstract 

Objective

To investigate the safety of sentinel node mapping for patients with early-stage cervical cancer undergoing cervical conization plus nodal evaluation.

Methods

The ETERNITY project is a retrospective, multi-institutional study collecting data of patients with early-stage cervical cancer undergoing fertility-sparing treatment. Here, we compared outcomes related to three methods of nodal assessment: sentinel node mapping (SNM), SNM plus backup lymphadenectomy (SNM + LND); pelvic lymphadenectomy (LND).

Results

Charts of 123 patients (with stage IA1-IB1 cervical cancer) were evaluated. Median patients' age was 34 (range, 22-44) years. SNM, SNM + LND, and LND were performed in 32 (26 %), 31 (25.2 %), and 60 (48.8 %) patients, respectively. Overall, eight (6.5 %) patients were diagnosed with positive nodes. Two (3.3 %), three (9.7 %), and three (9.4 %) patients were detected in patients who had LND, SNM + LND, and SNM respectively. Considering the 63 patients undergoing SNM (31 SNM + LND and 32 SNM alone), macrometastases, micrometastases, and isolated tumor cells were detected in four (3.2 %), three (2.4 %), and one (0.8 %) patients, respectively. All patients with positive nodes discontinued the fertility sparing treatment. Other two patients (one (1.7 %) in the LND group and one (3.1 %) in the SNM group) required hysterectomy even after negative nodal evaluation. After a median follow-up of 53.6 (range, 1.3, 158.0) months, nine (7.3 %) and two (1.6 %) patients developed cervical and pelvic nodes recurrences, respectively. Disease-free (p = 0.332, log-rank test) and overall survival (p = 0.769, log-rank test) were similar among groups.

Conclusions

In this retrospective experience, SNM upholds long-term oncologic effectiveness of LND, reducing morbidity.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.ejso.2024.108467

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