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Defining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration.

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Affiliations

  • 1. Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
      Authors
    • Park MA 1, 13
    • Permuth JB 1, 12
    (2 authors)
  • 2. Department of Metabolism and Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
      Authors
    • Whelan CJ 2
    • McDonald P 2
    (2 authors)
  • 3. Department of Machine Learning, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
      Authors
    • Ahmed S 3
    • Rasool G 3
    (2 authors)
  • 4. Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
      Authors
    • Boeringer T 4
    • Pillai S 4
    (2 authors)
  • 5. Department of Cancer Biology and Evolution, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
      Authors
    • Brown J 5
    • West J 5
    (2 authors)
    • Show all (13)

ORCIDs linked to this article

Show all (10)

Cancers, 27 Jun 2024, 16(13):2364
https://doi.org/10.3390/cancers16132364 PMID: 39001427 

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Abstract 

For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with fat loss, decreased appetite, lower tolerance and poorer response to treatment, poor quality of life, and reduced survival. Unfortunately, there are no effective therapeutic interventions to completely reverse cancer cachexia and no FDA-approved pharmacologic agents; hence, new approaches are urgently needed. In May of 2022, researchers and clinicians from Moffitt Cancer Center held an inaugural retreat on CAC that aimed to review the state of the science, identify knowledge gaps and research priorities, and foster transdisciplinary collaborative research projects. This review summarizes research priorities that emerged from the retreat, examples of ongoing collaborations, and opportunities to move science forward. The highest priorities identified include the need to (1) evaluate patient-reported outcome (PRO) measures obtained in clinical practice and assess their use in improving CAC-related outcomes; (2) identify biomarkers (imaging, molecular, and/or behavioral) and novel analytic approaches to accurately predict the early onset of CAC and its progression; and (3) develop and test interventions (pharmacologic, nutritional, exercise-based, and through mathematical modeling) to prevent CAC progression and improve associated symptoms and outcomes.

Full text links 

Read article at publisher's site: https://doi.org/10.3390/cancers16132364

Read article for free, from open access legal sources, via Unpaywall: https://www.mdpi.com/2072-6694/16/13/2364/pdf?version=1720603656Unpaywall

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Funding 

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NCI NIH HHS (1)

NINR NIH HHS (1)

United States Department of Defense (1)