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Tailored Bioactive Glass Coating: Navigating Devitrification Toward a Superior Implant Performance.

Author information

Affiliations

  • 1. Specialty Glass Division, CSIR-Central Glass & Ceramic Research Institute, 196, Raja S C Mullick Road, Kolkata 700032, India.
      Authors
    • Chakraborty A 1, 2
    • Tah I 1
    • Biswas K 1, 2
    (3 authors)
  • 2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, India.
      Authors
    • Chakraborty A 1, 2
    • Bodhak S 2, 3
    • Kant S 2, 7
    • Allu AR 2
    • Biswas K 1, 2
    (5 authors)
  • 3. Bioceramics and Coating Division, CSIR-Central Glass & Ceramic Research Institute, 196, Raja S C Mullick Road, Kolkata 700032, India.
      Authors
    • Bodhak S 2, 3
    • Saha D 3
    (2 authors)
  • 4. Department of Physics, Dr. Harisingh Gour Central University, Sagar 470003, Madhya Pradesh, India.
      Authors
    • Dey KK 4
    (1 author)
  • 5. Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
      Authors
    • Gupta N 5
    (1 author)
    • Show all (7)

ORCIDs linked to this article

ACS Biomaterials Science & Engineering, 01 Aug 2024, 10(8):5300-5312
https://doi.org/10.1021/acsbiomaterials.4c01032 PMID: 39087496 

Abstract 

The development of well-adherent, amorphous, and bioactive glass coatings for metallic implants remains a critical challenge in biomedical engineering. Traditional bioactive glasses are susceptible to crystallization and exhibit a thermal expansion mismatch with implant materials. This study introduces a novel approach to overcome these limitations by employing systematic Na2O substitution with CaO in borosilicate glasses. In-depth structural analysis (MD simulations, Raman spectroscopy, and NMR) reveals a denser network with smaller silicate rings, enhancing thermal stability, reducing thermal expansion, and influencing dissolution kinetics. This tailored composition exhibited optimal bioactivity (in vitro formation of bone-like apatite within 3 days) and a coefficient of thermal expansion closely matching Ti-6Al-4V, a widely used implant material. Furthermore, a consolidation process, meticulously designed with insights from crystallization kinetics and the viscosity-temperature relationship, yielded a crack-free, amorphous coating on Ti-6Al-4V substrates. This novel coating demonstrates excellent cytocompatibility and strong antibacterial action, suggesting superior clinical potential compared with existing technologies.

Full text links 

Read article at publisher's site: https://doi.org/10.1021/acsbiomaterials.4c01032

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Funding 

Funders who supported this work.

Council of Scientific and Industrial Research, India (2)