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Performance of bowel preparation quality scales in patients with Crohn's disease.

Author information

Affiliations

  • 1. Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada.
      Authors
    • Solitano V 1, 5
    • Sedano R 1, 5
    • McDonald JWD 1, 5
    • Feagan BG 1, 5
    • Jairath V 1, 5
    (5 authors)
  • 2. Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
      Authors
    • Siegel CA 2
    (1 author)
  • 3. Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
      Authors
    • Korzenik JR 3
    (1 author)
  • 4. Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
      Authors
    • Maratt JK 4
    • Rex DK 4
    (2 authors)
  • 5. Alimentiv Inc, London, Ontario, Canada.
      Authors
    • Solitano V 1, 5
    • Maguire B 5
    • Sedano R 1, 5
    • McDonald JWD 1, 5
    • Remillard J 5
    • Shackelton LM 5
    • Zou G 5
    • Feagan BG 1, 5
    • Ma C 5
    • Jairath V 1, 5
    (10 authors)
    • Show all (7)

ORCIDs linked to this article

Alimentary Pharmacology & Therapeutics, 11 Aug 2024, 60(8):1042-1050
https://doi.org/10.1111/apt.18210 PMID: 39129393 

Abstract 

Background

The performance of bowel preparation (BP) in patients with Crohn's disease (CD) is unknown.

Aims

To evaluate the operating properties of instruments used to assess BP quality in patients with CD.

Methods

We used the Boston Bowel Preparation Scale, modified Boston Bowel Preparation Scale, Harefield Cleansing Scale, Food and Drug Administration Bowel Cleansing Assessment Scale (BCAS), and a 100-mm visual analogue scale of bowel cleanliness to assess BP quality in 50 videos from 40 patients with CD. We assessed endoscopic activity with the Simple Endoscopic Score for CD (SES-CD). Assessments were on endoscope insertion and withdrawal. Reliability was quantified using the intraclass correlation coefficient (ICC). We assessed validity by within-patient correlation between instruments and the visual analogue scale using mixed-effect models. The correlation between BP quality and SES-SD scores was assessed using Spearman's rho.

Results

Inter- and intra-rater reliability for all BP quality instruments was substantial (ICC ≥0.61) except for the Food and Drug Administration BCAS on insertion (inter-rater reliability ICC ≥0.41). The visual analogue scale had substantial inter- and almost perfect (ICC ≥0.81) intra-rater reliability. Correlation coefficients for the validity of the instruments exceeded 0.58. BP quality and endoscopic disease activity scores in the colon were negatively correlated.

Conclusion

Most existing instruments reliably assess BP quality in patients with CD. These results support the use of these instruments in clinical practice, provide a framework for scoring BP quality in CD clinical trials, and support evaluation of novel BP agents in patients with CD.

Full text links 

Read article at publisher's site: https://doi.org/10.1111/apt.18210

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Funding 

Funders who supported this work.

Leona M. and Harry B. Helmsley Charitable Trust (2)