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Multifunctional targeting of docetaxel plus bakuchiol micelles in the treatment of invasion and metastasis of ovarian cancer.

Author information

Affiliations

  • 1. Shandong Institute for Food and Drug Control, Shandong 250101, People's Republic of China.
      Authors
    • Li QY 1
    • Yu HY 1
    • Liu CL 1
    • Diao FY 1
    • Jiang YQ 1
    • Lin YQ 1
    • Wang WJ 1
    (7 authors)
  • 2. Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong 250011, People's Republic of China.
      Authors
    • Zhu RR 2
    (1 author)
  • 3. Liaoning University of Traditional Chinese Medicine, School of Pharmacy, Dalian 116600, People's Republic of China.
      Authors
    • Li XT 3
    (1 author)

ORCIDs linked to this article

Biomedical Materials (Bristol, England), 05 Sep 2024, 19(6)
https://doi.org/10.1088/1748-605x/ad7556 PMID: 39208838 

Abstract 

The invasion and metastasis of tumors pose significant challenges in the treatment of ovarian cancer (OC), making it difficult to cure. One potential treatment approach that has gained attention is the use of matrix metalloproteinase reactive controlled release micelle preparations. In this study, we developed a novel PEG5000-PVGLIG-hyaluronic acid docetaxel/bakuchiol (PP-HA-DTX/BAK) micelles formulation with desirable characteristics such as particle size, narrow polydispersity index, and a ZETA potential of approximately -5 mV. The surface modification with HA facilitates tumor penetration into the tumor interior, while the incorporation of DSPE-PEG2000-PVGLIG-PEG5000helps conceal DSPE-PEG2000-HA, reducing off-target effects and prolonging drug circulation timein vivo. Bothin vitroandin vivoexperiments demonstrated that these micelles effectively inhibit proliferation, invasion, and metastasis of OC cells while promoting apoptosis. Therefore, our findings suggest that PP-HA-DTX/BAK micelles represent a safe and effective therapeutic strategy for treating OC.

Full text links 

Read article at publisher's site: https://doi.org/10.1088/1748-605x/ad7556

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Funding 

Funders who supported this work.

the Open Project of the Key Laboratory of Cosmetic Raw Material Quality Control of the National Medical Products Administration (1)