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Liposomal formulation of a gold(III) metalloantibiotic: a promising strategy against antimicrobial resistance.

Author information

Affiliations

  • 1. Nanovex Biotechnologies S.L., Parque Tecnológico de Asturias Edificio CEEI, 33428 Llanera, Spain.
      Authors
    • Llamedo A 1, 3
    • Rodríguez P 1
    (2 authors)
  • 2. ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
      Authors
    • Gabasa Y 2
    • Soto SM 2
    (2 authors)
  • 3. Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.
      Authors
    • Llamedo A 1, 3
    • Soengas RG 3
    • Rodríguez-Solla H 3
    • Elorriaga D 3
    • García-Alonso FJ 3
    (5 authors)

ORCIDs linked to this article

Dalton Transactions (Cambridge, England : 2003), 18 Sep 2024, 53(36):15205-15214
https://doi.org/10.1039/d4dt01867b PMID: 39221630 

Abstract 

A novel lipoformulation was developed by encapsulating cationic (S^C)-cyclometallated gold(III) complex [Au(dppta)(N2Py-PZ-dtc)]+ (AuPyPZ) in liposomes. The liposomal form of compound AuPyPZ has a bactericidal action similar to that of the free drug without any appreciable effect on the viability of mammalian cells. Furthermore, the nanoformulation reduces metalloantibiotic-induced inhibition of hERG and the inhibition of cytochromes, significantly decreasing the potential liabilities of the metallodrug. The obtained metalloantibiotic liposomal formulation shows high stability and suitable properties for drug delivery, representing an effective strategy to fight against drug-resistant bacteria.

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Read article at publisher's site: https://doi.org/10.1039/d4dt01867b

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Funding 

Funders who supported this work.

Instituto de Salud Carlos III (4)

Ministerio de Economía y Competitividad (1)