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Blood flow signals through the bone cortex on ultrasonography can be used as a screening test for detecting bone marrow lesions on magnetic resonance imaging in patients with early knee osteoarthritis.

Author information

Affiliations

  • 1. Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan.
      Authors
    • Takemoto N 1
    • Takata Y 1
    • Demura S 1
    • Nakase J 1
    (4 authors)
  • 2. Department of Orthopedic Surgery, KKR Hokuriku Hospital, Kanazawa, Ishikawa, 921-8035, Japan.
      Authors
    • Shima Y 2
    • Kanayama T 2
    (2 authors)
  • 3. Department of Orthopedic Surgery and Joint Reconstructive Surgery, Kanazawa Munehiro Hospital, Kanazawa, Ishikawa, 920-0923, Japan.
      Authors
    • Goshima K 3
    (1 author)
  • 4. Department of Orthopedic Surgery, Nomi Municipal Hospital, Nomi, Ishikawa, 929-0122, Japan.
      Authors
    • Shimozaki K 4
    (1 author)
  • 5. Department of Orthopedic Surgery, Fukui General Hospital, Fukui, 910-3113, Japan.
      Authors
    • Kimura M 5
    (1 author)

ORCIDs linked to this article

Journal of Medical Ultrasonics (2001), 04 Oct 2024,
https://doi.org/10.1007/s10396-024-01503-2 PMID: 39365403 

Abstract 

Purpose

Blood flow signals (BFSs) through the bone cortex on ultrasonography (US) and bone marrow lesions (BMLs) detected on magnetic resonance imaging (MRI) can be used to assess bone lesions; however, no studies have reported their relationship. Therefore, this study aimed to assess whether BFSs through the bone cortex on US can serve as a screening test for detecting BMLs on MRI in patients with early knee osteoarthritis (OA).

Methods

This study enrolled patients with knee joint pain who were diagnosed with early knee OA between January 2018 and January 2024. We targeted 77 patients who underwent MRI and in whom the presence or absence of BFSs through the bone cortex was confirmed on US. The association between BFSs and BMLs was evaluated using the chi-square test, and the sensitivity and specificity of BFSs for detecting BMLs on MRI were calculated.

Results

The chi-square test showed that BFSs and BMLs were significantly associated in the femur and tibia (femur: χ2 [1] = 52.9, p < 0.001; Tibia: χ2 [1] = 44.8, p < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of BFSs for detecting BMLs on MRI were 85.0%, 96.5%, 89.5%, and 94.8%, respectively, for the femur, and 84.0%, 92.3%, 84.0%, and 92.3%, respectively, for the tibia.

Conclusion

BFSs through the bone cortex on US can be used as a screening test for detecting BMLs on MRI in patients with early knee OA.

Full text links 

Read article at publisher's site: https://doi.org/10.1007/s10396-024-01503-2

References 

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