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Current management of hepatobiliary malignancies between centers with or without a liver transplant program: A multi-society national survey.

Collaborators (76)

Author information

Affiliations

  • 1. Hepatobiliary Surgery and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
      Authors
    • Serenari M 1
    • Contributors
      Ravaioli M 1
    (2 authors)
  • 2. HPB and Transplant Unit, Department of Surgical Sciences, University of Rome Tor Vergata, Rome Italy.
      Authors
    • Angelico R 2
    (1 author)
  • 3. General Surgery and Organ Transplantation Unit, AOU Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
      Authors
    • Lai Q 3
    (1 author)
  • 4. General Surgery 2U-Liver Transplant Unit, Department of Surgical Sciences, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Università di Torino, Corso Bramante 88-90, 10126 Turin, Italy.
      Authors
    • Patrono D 4
    (1 author)
  • 5. Hepatobiliary Surgery and Liver Transplant Unit, Department of Precision and Regenerative Medicine and Ionian Area, A.O.U. Policlinico di Bari - University of Bari, Piazza Giulio Cesare 11, Padiglione Asclepios 70124, Bari.
      Authors
    • Scalera I 5
    • Contributors
      Tandoi F 5
    (2 authors)
    • Show all (9)

ORCIDs linked to this article

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 07 Oct 2024, :S1590-8658(24)01007-7
https://doi.org/10.1016/j.dld.2024.09.007 PMID: 39379228 

Abstract 

Background

Availability of liver transplantation (LT) as a treatment for hepatocellular carcinoma (HCC) and other liver malignancies may determine heterogeneity of therapeutic strategies across different centers.

Aims

To investigate the practice between hepato-biliary centers without (HB centers) and with a LT program (LT centers), we launched a 38-item web-based national survey, with directors of centers as a target.

Methods

The survey, including 4 clinical vignettes, collected data on their approach to HCC and transplant oncology.

Results

After duplicates removal, 75 respondents were considered. Respondents from LT centers (n = 22, 29.3 %) were more in favor of LT in the case of HCC outside Milan criteria (90.9 % vs. 67.9 %, p = 0.037), recurrent HCC (95.5 % vs. 50.9 %, p = 0.002) and other malignancies such as cholangiocarcinoma or neuroendocrine tumors. No significant difference was observed concerning the proportion of centers favorable to LT for unresectable colorectal liver metastases (100 % vs. 88.7 %, p = 0.100).

Conclusion

This national survey showed how management of HCC and awareness of transplant oncology may differ between HB and LT centers. Effective networking between HB and LT centers is crucial to provide optimal treatment and access to LT.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.dld.2024.09.007

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