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Optimal Diagnostic and Treatment Response Threshold of the Eosinophilic Esophagitis Endoscopic Reference Score: A Single-Center Study of 102 Patients With Eosinophilic Esophagitis.

Author information

Affiliations

  • 1. Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.
      Authors
    • Park K 1
    (1 author)
  • 2. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
      Authors
    • Ahn B 2
    • Park YS 2
    (2 authors)
  • 3. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
      Authors
    • Jung KW 3
    • Na HK 3
    • Ahn JY 3
    • Lee JH 3
    • Kim DH 3
    • Choi KD 3
    • Song HJ 3
    • Lee GH 3
    • Jung HY 3
    (9 authors)
  • 4. Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Chungcheongbuk-do, Korea.
      Authors
    • Lee JS 4
    (1 author)
  • 5. Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
      Authors
    • Kim GH 5
    (1 author)

ORCIDs linked to this article

Journal of Neurogastroenterology and Motility, 01 Oct 2024, 30(4):430-436
https://doi.org/10.5056/jnm23172 PMID: 39397620 PMCID: PMC11474565

This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Abstract 

Background/aims

The proposed eosinophilic esophagitis (EoE) endoscopic reference score serves to diagnose and evaluate treatment responses in EoE. Nevertheless, the validated reference score thresholds for diagnosis and treatment response in Asian patients are yet to be established. This study aims to establish these thresholds for the first time among Asian patients with EoE.

Methods

Patients presenting with ≥ 15 eosinophils/high power field and esophageal dysfunction symptoms between August 2007 and November 2021 were included. Age- and sex-matched non-EoE controls were also enrolled. Baseline characteristics, endoscopic reference score features, and scores were compared between patients and controls. Among patients, endoscopic reference score features and scores, along with peak eosinophil counts, were evaluated both before and after treatment. The optimal threshold was determined based on sensitivity, specificity, and the Youden index.

Results

Overall, 102 patients were enrolled (74.5% men; mean age, 46.9 years). The mean endoscopic reference score was 2.65 and 0.52 for patients and controls, respectively (P < 0.001). An endoscopic reference score ≥ 2 was identified as the optimal diagnostic threshold for EoE (sensitivity, 0.79; specificity, 0.86; Youden index, 0.66). Post-treatment data regarding endoscopic findings and histology were available for 30 patients. Regarding histologic response, an endoscopic reference score of ≤ 3 demonstrated the optimal threshold (sensitivity, 0.95; specificity, 0.88; Youden index, 0.83).

Conclusions

The optimal diagnostic and treatment response thresholds were determined to be endoscopic reference scores of ≥ 2 and ≤ 3, respectively. Further studies involving a larger patient cohort are necessary to validate these findings.

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Time: 2024/11/20 01:50:23

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Read article at publisher's site: https://doi.org/10.5056/jnm23172

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