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Regional response to light illuminance across the human hypothalamus.

Author information

Affiliations

  • 1. GIGA-CRC Human Imaging, University of Liège, Liège, Belgium.
      Authors
    • Campbell I 1
    • Sharifpour R 1
    • Balda Aizpurua JF 1
    • Beckers E 1
    • Paparella I 1
    • Berger A 1
    • Koshmanova E 1
    • Mortazavi N 1
    • Read J 1
    • Zubkov M 1
    • Talwar P 1
    • Collette F 1
    • Sherif S 1
    • Phillips C 1
    • Lamalle L 1
    • Vandewalle G 1
    (16 authors)

ORCIDs linked to this article

Elife, 28 Oct 2024, 13:RP96576
https://doi.org/10.7554/elife.96576 PMID: 39466317 PMCID: PMC11517251

This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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This article is based on a previously available preprint.

Abstract 

Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, the subcortical circuitry underlying the stimulating impact of light is not established in humans. We used 7 Tesla functional magnetic resonance imaging to assess the impact of variations in light illuminance on the regional activity of the hypothalamus while healthy young adults (N=26; 16 women; 24.3±2.9 y) were completing two auditory cognitive tasks. We find that, during both the executive and emotional tasks, higher illuminance triggered an activity increase over the posterior part of the hypothalamus, which includes part of the tuberomamillary nucleus and the posterior part of the lateral hypothalamus. In contrast, increasing illuminance evoked a decrease in activity over the anterior and ventral parts of the hypothalamus, encompassing notably the suprachiasmatic nucleus and another part of the tuberomammillary nucleus. Critically, the performance of the executive task was improved under higher illuminance and was negatively correlated with the activity of the posterior hypothalamus area. These findings reveal the distinct local dynamics of different hypothalamus regions that underlie the impact of light on cognition.

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Time: 2024/11/20 04:31:32

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Read article at publisher's site: https://doi.org/10.7554/elife.96576

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Funding 

Funders who supported this work.

European Regional Development Fund (1)

Fondation Léon Frédéricq

    Fonds De La Recherche Scientifique - FNRS Belgium (1)

    JPND - EU Joint-Programme Neurodegenerative Disease Research (2)

    Marie Sklodowska-Curie Actions (1)

    ULiège - U. Maastricht Imaging Valley

      ULiège-Valeo Innovation Chair "Health and Well-Being in Transport" and Sanfran (1)

      • Grant ID: LIGHT-CABIN

        0 publications

      ULiège-Valeo Innovation Chair "Health and Well-Being in Transport" and Sanfran (1)