Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Interfacility Transfer for Thrombectomy: A Promising Therapeutic Window.

Author information

Affiliations

  • 1. Neurology Department, Rothschild Foundation Hospital, Paris, France (P.S.).
      Authors
    • Seners P 1, 2, 4
    (1 author)
  • 2. Institut de Psychiatrie et Neurosciences de Paris, U1266, INSERM, France (P.S., J.-C.B.).
      Authors
    • Seners P 1, 2, 4
    • Baron JC 2
    (2 authors)
  • 3. KU Leuven, Department of Neurosciences, Experimental Neurology; University Hospitals Leuven, Department of Neurology, Belgium (A.W., R.L.).
      Authors
    • Wouters A 3
    • Lemmens R 3
    (2 authors)
  • 4. StrokeLink, French Clinical Research Infrastructure Network (F-CRIN), France (P.S., J.-P.D., F.P., R.M., J.-M.O.).
      Authors
    • Seners P 1, 2, 4
    • Desilles JP 4
    • Pico F 4
    • Macrez R 4
    • Olivot JM 4
    (5 authors)
  • 5. Stanford Stroke Center, Stanford University, Palo Alto, CA (G.W.A., M.G.L.).
      Authors
    • Albers GW 5
    • Lansberg MG 5
    (2 authors)

ORCIDs linked to this article

Show all (10)

Stroke, 06 Nov 2024,
https://doi.org/10.1161/strokeaha.124.049167 PMID: 39502034 

Review

Abstract 

Currently, most acute ischemic stroke patients presenting with a large vessel occlusion are first evaluated at a nonthrombectomy-capable center before transfer to a comprehensive stroke center that performs thrombectomy. Interfacility transfer is a complex process that requires extensive coordination between the referring, transporting, and receiving facilities. As a result, long delays are common, contributing to poor clinical outcomes. In this review, we summarize the accumulating literature about the clinical as well as radiological-infarct growth, collateral change, arterial recanalization, and hemorrhagic transformation-changes during interfacility transfer for thrombectomy. Recent evidence shows that clinical/radiological changes during transfer are heterogeneous across patients and impact long-term functional outcomes, highlighting the urgent need to optimize care during this time window. We review some of the most promising therapeutic strategies-for example, penumbral protection to reduce infarct growth-that may improve clinical outcome in patients being transferred to thrombectomy-capable centers. Finally, we discuss key methodological considerations for designing clinical trials aimed at reducing infarct growth during transfer.

Full text links 

Read article at publisher's site: https://doi.org/10.1161/strokeaha.124.049167

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.