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Ultrasensitive In<sub>2</sub>O<sub>3</sub>-Based Nanoflakes for Lung Cancer Diagnosis and the Sensing Mechanism Investigated by <i>Operando</i> Spectroscopy.

Author information

Affiliations

  • 1. Polytechnic Institute of Zhejiang University, Institute of Zhejiang University-Quzhou, Quzhou 324000, China.
      Authors
    • Cheng Y 1, 4
    • Mao Y 1
    • Lim KH 1, 4
    • Zheng J 1, 4
    • Wang Q 1, 4
    (5 authors)
  • 2. Instituto de Catálisis y Petroleoquímica, Consejo Superior de Investigaciones Científicas (CSIC), Madrid E-28049, Spain.
      Authors
    • Portela R 2
    • Bañares MA 2
    (2 authors)
  • 3. Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310001, China.
      Authors
    • Wang P 3
    • Zhang G 3
    • Ding L 3
    (3 authors)
  • 4. State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310012, China.
      Authors
    • Cheng Y 1, 4
    • Liu P 4
    • Lim KH 1, 4
    • Zheng J 1, 4
    • Yang X 4
    • Wang WJ 4
    • Li BG 4
    • Wang Q 1, 4
    (8 authors)

ORCIDs linked to this article

Show all (9)

ACS Sensors, 06 Nov 2024,
https://doi.org/10.1021/acssensors.4c01298 PMID: 39503359 

Abstract 

Rapid gas sensing with high sensitivity and selectivity is pivotal in advanced production, in smart living, and increasingly in medical health applications. This study presents a novel Pt@InNiOx nanoflake isoprene sensor that achieves an exceptionally low limit of detection (LOD) at 2 ppb, the lowest reported for isoprene sensors to date. Notably, it exhibits high selectivity and remarkable antihumidity capacity, thus meeting the stringent requirements for lung cancer screening. To unravel the sensing mechanism, we fabricate an operando DRIFTS-Raman cell coupled to online electrical measurements. It reveals that the ultrasensitive performance of Pt@InNiOx nanoflakes stems from the activated conjugated structure of isoprene by Pt nanoclusters and from the enhanced isoprene adsorption and electron interaction due to the nanoflake morphology. The p-n junction constructed by doping Ni maintains Fermi level equilibrium, shielding it from humidity interference. Practically, we integrate these ultrasensitive Pt@InNiOx nanoflakes into a miniaturized portable electronic device that successfully distinguishes lung cancer patients with expiratory isoprene below 40 ppb, from the healthy population with isoprene above 60 ppb, enabling an accurate diagnosis in clinics. Our work not only provides a breakthrough in low-cost, noninvasive cancer screening through breath analysis but also advances the rational design of cutting-edge gas sensing materials.

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Read article at publisher's site: https://doi.org/10.1021/acssensors.4c01298

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Funding 

Funders who supported this work.

Institute of Zhejiang University-Quzhou (6)

National Key Research and Development Program of China (1)

National Natural Science Foundation of China (3)

Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering (1)

State Key Laboratory of Chemical Engineering (1)

State Key Laboratory of Electrical Insulation and Power Equipment (1)