Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy.

Hassold T; Chiu D

doi:10.1007/bf00389450

Abstract

The effect of maternal age on the incidence of chromosomally normal spontaneous abortion and different categories of chromosome abnormality among all clinically recognized human pregnancies was evaluated. The results provide no evidence for a significant association of age with sex chromosome monosomy or polyploidy, but clearly demonstrate an effect of age on the frequency of trisomy and chromosomally normal spontaneous abortions. Estimated maternal age-specific rates of trisomy among all recognized pregnancies were calculated and suggest that a majority of oocytes of women aged 40 years and older may be aneuploid.

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References

Articles referenced by this article (23)

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Hassold T, Warburton D, Kline J, Stein Z (to be published) The relationship of maternal age and trisomy among trisomic spontaneous abortions. Am J Hum Genet
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NICHD NIH HHS (1)

Grant ID: HD 07879
21 publications

Search life-sciences literature (45,103,589 articles, preprints and more)

Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy.

Abstract

Full text links

References

Maternal-age effect in aneuploidy: does altered embryonic selection play a role?

ANALYSIS OF THE OUTCOME OF ALL PREGNANCIES IN A COMMUNITY.KAUAI PREGNANCY STUDY.

Parental age and birth order in the aetiology of some sex chromosome aneuploidies.

Ferguson-Smith MA (1979) Group report: Maternal age-specific incidence of chromosome aberrations at amniocentesis. In: Murken J-D, Stengel-Rutkowski S, Schwinger E (eds) Prenatal diagnosis. Enke, Stuttgart, pp 1-14

Trisomy in man.

A cytogenetic study of 1000 spontaneous abortions.

Hassold T, Warburton D, Kline J, Stein Z (to be published) The relationship of maternal age and trisomy among trisomic spontaneous abortions. Am J Hum Genet

Hook EB (1981a) Down syndrome: Its frequency in human populations and some factors pertinent to variation in rates. In: de la Cruz F, Gerald P (eds) Trisomy 21 (Down syndrome) ? Research perspectives. University Park Press, Baltimore, pp 3-67

Rates of chromosome abnormalities at different maternal ages.

Prevalence of chromosome abnormalities during human gestation and implications for studies of environmental mutagens.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1007/bf00389450

Article citations

Acute postoperative complications after spine deformity correction in patients with Down syndrome.

Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster.

Insights into embryonic chromosomal instability: mechanisms of DNA elimination during mammalian preimplantation development.

Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.

Embryo ploidy in vitrified versus fresh oocytes: Is there a difference?

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Funding

NICHD NIH HHS (1)

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Search life-sciences literature (45,103,589 articles, preprints and more)

Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy.

Abstract

Full text links

References

Ferguson-Smith MA (1979) Group report: Maternal age-specific incidence of chromosome aberrations at amniocentesis. In: Murken J-D, Stengel-Rutkowski S, Schwinger E (eds) Prenatal diagnosis. Enke, Stuttgart, pp 1-14

Hassold T, Warburton D, Kline J, Stein Z (to be published) The relationship of maternal age and trisomy among trisomic spontaneous abortions. Am J Hum Genet

Hook EB (1981a) Down syndrome: Its frequency in human populations and some factors pertinent to variation in rates. In: de la Cruz F, Gerald P (eds) Trisomy 21 (Down syndrome) ? Research perspectives. University Park Press, Baltimore, pp 3-67

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NICHD NIH HHS (1)﻿

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