Molecular cloning of cDNA encoding human interleukin-2 receptor.

Nikaido T; Shimizu A; Ishida N; Sabe H; Teshigawara K; Maeda M; Uchiyama T; Yodoi J; Honjo T

doi:10.1038/311631a0

Abstract

The human interleukin-2 (IL-2) receptor was purified by affinity chromatography using the anti-Tac monoclonal antibody, and its N-terminal amino acid sequence was determined. Complementary DNA clones were isolated and sequenced to reveal the primary structure of the IL-2 receptor precursor, which has 272 amino acid residues. The receptor is separated into two domains by a putative 19-residue transmembrane region. Two mRNAs (1.4 and 3.5 kilobases) hybridizing to the cDNA clone were found in human T cells bearing the IL-2 receptor. The cDNA directed synthesis of the IL-2 receptor in COS cells.

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References

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Diseases in OMIM

INTERLEUKIN 2 RECEPTOR, ALPHA; IL2RA(OMIM - 147730)

Proteins in UniProt

Interleukin-2 receptor subunit alpha(UniProt - P01589)

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Molecular cloning of cDNA encoding human interleukin-2 receptor.

Abstract

Full text links

References

Selective in vitro growth of T lymphocytes from normal human bone marrows.

T-cell growth factor.

T cell growth factor receptors. Quantitation, specificity, and biological relevance.

Transient expression of interleukin 2 receptors. Consequences for T cell growth.

Characterization of the human receptor for T-cell growth factor.

Wano, Y. et al. J. Immun. (in the press).

Structure and expression of a cloned cDNA for human interleukin-2.

Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.

Yachie, A. et al. J. Immun. 131, 731–735 (1983).

Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1.

Mathematical model for IL-2-based cancer immunotherapy.

Interleukins in the treatment of melanoma.

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.

Dynamic Roles for IL-2-STAT5 Signaling in Effector and Regulatory CD4⁺ T Cell Populations.

Data

Data that cites the article

Diseases in OMIM

Proteins in UniProt

Nucleotide sequences in ENA (Showing 5 of 14)

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