Structural comparison of glycophorins and immunochemical analysis of genetic variants.

Furthmayr H

doi:10.1038/271519a0

Abstract

Differences in amino acid sequence of erythrocyte membrane glycophorin A are correlated with M or N blood group activity. A second sialoglycoprotein, glycophorin B, has an amino acid sequence identical to that of glycophorin AN in the first 23 positions and carries N activity only, suggesting that different structural genes code for the glycoproteins carrying these antigens. Certain genetically variant cells lack glycophorin A, as determined by immunochemical methods, and serological MN activity. Other variants lack MN activity, but contain normal amounts of glycophorin A in the membrane.

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References

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Landsteiner, K. & Levine, P. Proc. Soc. exp. Biol. N.Y. 24, 600–602 (1927).
Walsh, R. J. & Montgomery, C. Nature 160, 504 (1947).
Race, R. R. & Sanger, R. in Blood Groups in Man, 92–138, 463–496 (Blackwell, 1975).
Solubilization of human erythrocyte membrane glycoproteins and separation of the MN glycoprotein from a glycoprotein with I, S, and A activity.
Hamaguchi H, Cleve H
Biochim Biophys Acta, (2):271-280 1972
MED: 4673526
Some new observations on the MN system.
ALLEN FH, CORCORAN PA, ELLIS FR
Vox Sang, 224-231 1960
MED: 13848771
INACTIVATION OF HUMAN ERYTHROCYTE AGGLUTINOGENS M AND N BY INFLUENZA VIRUSES AND RECEPTOR-DESTROYING ENZYME.
Springer GF, Ansell NJ
Proc Natl Acad Sci U S A, (2):182-189 1958
MED: 16590164
Anti-N reagents in elucidation of the genetical basis of human blood-group MN specificities.
Springer GF, Tegtmeyer H, Huprikar SV
Vox Sang, (4):325-343 1972
MED: 4111981
Springer, G. F. & Stalder, K. Nature 191, 187–188 (1961).
The membrane change in En(a-) human erythrocytes. Absence of the major erythrocyte sialoglycoprotein.
Tanner MJ, Anstee DJ
Biochem J, (2):271-277 1976
MED: 1275890
Studies on the membrane glycoprotein defect of En(a-) erythrocytes. I. Biochemical aspects.
Dahr W, Uhlenbruck G, Leikola J, Wagstaff W, Landfried K
J Immunogenet, (5):329-346 1976
MED: 1010946

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Structural comparison of glycophorins and immunochemical analysis of genetic variants.

Abstract

Full text links

References

Landsteiner, K. & Levine, P. Proc. Soc. exp. Biol. N.Y. 24, 600–602 (1927).

Walsh, R. J. & Montgomery, C. Nature 160, 504 (1947).

Race, R. R. & Sanger, R. in Blood Groups in Man, 92–138, 463–496 (Blackwell, 1975).

Solubilization of human erythrocyte membrane glycoproteins and separation of the MN glycoprotein from a glycoprotein with I, S, and A activity.

Some new observations on the MN system.

INACTIVATION OF HUMAN ERYTHROCYTE AGGLUTINOGENS M AND N BY INFLUENZA VIRUSES AND RECEPTOR-DESTROYING ENZYME.

Anti-N reagents in elucidation of the genetical basis of human blood-group MN specificities.

Springer, G. F. & Stalder, K. Nature 191, 187–188 (1961).

The membrane change in En(a-) human erythrocytes. Absence of the major erythrocyte sialoglycoprotein.

Studies on the membrane glycoprotein defect of En(a-) erythrocytes. I. Biochemical aspects.

Citations & impact

Impact metrics

Citations of article over time

Article citations

A 2,000-year-old specimen with intraerythrocytic Bartonella quintana.

A Comprehensive Review of Our Current Understanding of Red Blood Cell (RBC) Glycoproteins.

Structure of a sialo-oligosaccharide from glycophorin in carp red blood cell membranes.

Isolation and characterization of glycophorin from carp red blood cell membranes.

Sixty years of antibodies to MNS system hybrid glycophorins: what have we learned?

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