A new class of angiotensin-converting enzyme inhibitors.

Much current attention focuses on the renin-angiotensin system in relation to mechanisms controlling blood pressure and renal function. Recent demonstrations (ref. 1, ref. 2 and refs therein) that angiotensin-converting enzyme inhibitors show promising clinical antihypertensive properties have been of particular interest. We now report on the design of a novel series of substituted N-carboxymethyl-dipeptides which are active in inhibiting angiotensin-converting enzyme at nanomolar levels. We suggest that these compounds are transition-state inhibitors and that extensions of this design to other metalloendopeptidases merit further study.

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Articles referenced by this article (20)

An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients.
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A new class of angiotensin-converting enzyme inhibitors.

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References

An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients.

Captopril in the treatment of clinical hypertension and cardiac failure.

The existence of two forms of hypertensin.

A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.

Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents.

Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids.

Levine, W. G. in The Pharmacological Basis of Therapeutics 5th edn (eds Goodman, L. S. & Gilman, A.) 919–920 (Macmillan, New York, 1975).

Cushman, D. W., Cheung, H. S., Sabo, E. F. & Ondetti, M. A. Fedn Proc. 33, 2778–2782 (1979).

Angiotensin-converting enzyme and the regulation of vasoactive peptides.

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

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Article citations

Natural Products That Contain Higher Homologated Amino Acids.

Preparation, Purification and Characterization of Antibacterial and ACE Inhibitory Peptides from Head Protein Hydrolysate of Kuruma Shrimp, Marsupenaeus japonicus.

Modular Synthesis of α,α-Diaryl α-Amino Esters via Bi(V)-Mediated Arylation/S_N2-Displacement of Kukhtin-Ramirez Intermediates.

Natural products and drug discovery.

Design, Synthesis, and Study of a Novel RXPA380-Proline Hybrid (RXPA380-P) as an Antihypertensive Agent.

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Wikipedia

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