Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.

Saito H; Kranz DM; Takagaki Y; Hayday AC; Eisen HN; Tonegawa S

doi:10.1038/309757a0

Abstract

Two related, but distinct, cDNA clones have been isolated and sequenced from a functional murine cytotoxic T-lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and both have similarities to immunoglobulin variable and constant region genes. It is concluded that these genes code for the two subunits of the heterodimeric antigen receptor on the surface of the T cell; its complete deduced primary structure is presented.

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References

Articles referenced by this article (23)

Kindred, B. & Shreffler, D. C. J. Immun. 109, 940–943 (1972).
Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene.
Katz DH, Hamaoka T, Dorf ME, Maurer PH, Benacerraf B
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MED: 305459
H-2 antigens of the thymus determine lymphocyte specificity.
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Somatic generation of antibody diversity.
Tonegawa S
Nature, (5909):575-581 1983
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The T lymphocyte antigen receptor--paradigm lost.
Jensenius JC, Williams AF
Nature, (5893):583-588 1982
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Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.
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Data

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This data has been provided by curated databases and other sources that have cited the article.

Diseases in OMIM (2)

T-CELL RECEPTOR ALPHA CHAIN CONSTANT REGION; TRAC(OMIM - 186880)
T-CELL RECEPTOR GAMMA CHAIN CONSTANT REGION 1; TRGC1(OMIM - 186970)

Proteins in UniProt (Showing 5 of 6)

T-cell receptor beta chain V region PHDS203(UniProt - P01736)
T-cell receptor beta-2 chain C region(UniProt - P01851)
T-cell receptor gamma chain C region C10.5(UniProt - P01853)
Ig-like domain-containing protein(UniProt - A2NU22)
Ig-like domain-containing protein(UniProt - A2J008)

Go to all (6) records in UniProt

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/6330561

Mouse Genome Informatics (MGI)

http://www.informatics.jax.org/reference/6330561

Nucleotide sequences in ENA (4)

Murine mRNA for beta-subunit of T-cell receptor(ENA - X00696)
Murine mRNA for T-cell gamma gene(ENA - X00697)
Mus musculus (house mouse) hypothetical protein(ENA - CAA25293)
Mus musculus (house mouse) hypothetical protein(ENA - CAA25294)

The Rat Genome Database (RGD) was established in 1999 and rapidly became the premier site for genetic, genomic, phenotype, and disease-related data generated from rat research. In addition, RGD has expanded to include a large body of structured and standardized data for eight species (rat, mouse, human, chinchilla, bonobo, 13-lined ground squirrel, dog and pig). Much of this data is the result of manual curation work by RGD curators. In other instances, it has been imported into RGD from other databases through custom ELT (Extract, Load and Transform) pipelines giving RGD users integrated access to a wide variety of data to support their research efforts. RGD also offers a growing suite of innovative tools for querying, analyzing and visualizing this data making it a valuable resource for researchers worldwide.

https://rgd.mcw.edu/rgdweb/report/reference/main.html?id=11340365

Funding

Funders who supported this work.

NCI NIH HHS (3)

Grant ID: CA-28900
23 publications
Grant ID: CA-14051
76 publications
Grant ID: CA-28900-04
6 publications

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Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.

ORCIDs linked to this article

Abstract

Full text links

References

Kindred, B. & Shreffler, D. C. J. Immun. 109, 940–943 (1972).

Cell interactions between histoincompatible T and B lymphocytes. IV. Involvement of the immune response (Ir) gene in the control of lymphocyte interactions in responses controlled by the gene.

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

H-2 antigens of the thymus determine lymphocyte specificity.

Somatic generation of antibody diversity.

The T lymphocyte antigen receptor--paradigm lost.

Allison, J. P., McIntyre, B. W. & Bloch, D. J. Immun. 129, 2293–2300 (1982).

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Structures of human γδ T cell receptor-CD3 complex.

Advancements in γδT cell engineering: paving the way for enhanced cancer immunotherapy.

Interplay between Microbiota and γδ T Cells: Insights into Immune Homeostasis and Neuro-Immune Interactions.

γδ T cells: origin and fate, subsets, diseases and immunotherapy.

Local γδ T cells: translating promise to practice in cancer immunotherapy.

Data

Data that cites the article

Diseases in OMIM (2)

Proteins in UniProt (Showing 5 of 6)

Mouse Genome Informatics (MGI)

Nucleotide sequences in ENA (4)

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NCI NIH HHS (3)

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Search life-sciences literature (45,103,477 articles, preprints and more)

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.

Author information

ORCIDs linked to this article

Abstract

Full text links

References

Kindred, B. & Shreffler, D. C. J. Immun. 109, 940–943 (1972).

Allison, J. P., McIntyre, B. W. & Bloch, D. J. Immun. 129, 2293–2300 (1982).

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Data

Data that cites the article

Diseases in OMIM (2)

Proteins in UniProt (Showing 5 of 6)

Mouse Genome Informatics (MGI)

Nucleotide sequences in ENA (4)

Similar Articles

Funding

NCI NIH HHS (3)﻿

Partnerships & funding

NCI NIH HHS (3)