How signal sequences maintain cleavage specificity.

von Heijne G

doi:10.1016/0022-2836(84)90192-x

Abstract

The specificity of the signal sequence cleavage reaction has been postulated to reside in a signal peptidase active site that can bind only to particular (i, i + 2) pairs of amino acids. In this paper, we present further patterns of non-random amino acid utilization in a region around in vivo cleavage sites, and show that they can be interpreted in terms of selection acting to reduce the number of potential competing sites in the vicinity of the correct one.

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References

Articles referenced by this article (35)

Hamster preproglucagon contains the sequence of glucagon and two related peptides.
Bell GI, Santerre RF, Mullenbach GT
Nature, (5910):716-718 1983
MED: 6835407
A cDNA sequence encoding a rabbit heavy chain variable region of the VHa2 allotype showing homologies with human heavy chain sequences.
Bernstein KE, Reddy EP, Alexander CB, Mage RG
Nature, (5887):74-76 1982
MED: 6813744
Processing of filamentous phage pre-coat protein. Effect of sequence variations near the signal peptidase cleavage site.
Boeke JD, Russel M, Model P
J Mol Biol, (2):103-116 1980
MED: 7230262
Title not supplied
Chandra
1983
alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs.
Godine JE, Chin WW, Habener JF
J Biol Chem, (14):8368-8371 1982
MED: 6177696
Rat pre-prosomatostatin. Structure and processing by microsomal membranes.
Goodman RH, Aron DC, Roos BA
J Biol Chem, (9):5570-5573 1983
MED: 6133871
Title not supplied
Gurr
1983
Secretion of human interferons by yeast.
Hitzeman RA, Leung DW, Perry LJ, Kohr WJ, Levine HL, Goeddel DV
Science, (4585):620-625 1983
MED: 6186023
Miscleavage at the presequence of rat preprolactin synthesized in pituitary cells incubated with a threonine analog.
Hortin G, Boime I
Cell, (2):453-461 1981
MED: 6786757
Requirement for signal peptide cleavage of Escherichia coli prolipoprotein.
Inouye S, Hsu CP, Itakura K, Inouye M
Science, (4605):59-61 1983
MED: 6344218

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How signal sequences maintain cleavage specificity.

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Abstract

Full text links

References

Hamster preproglucagon contains the sequence of glucagon and two related peptides.

A cDNA sequence encoding a rabbit heavy chain variable region of the VHa2 allotype showing homologies with human heavy chain sequences.

Processing of filamentous phage pre-coat protein. Effect of sequence variations near the signal peptidase cleavage site.

Title not supplied

alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs.

Rat pre-prosomatostatin. Structure and processing by microsomal membranes.

Title not supplied

Secretion of human interferons by yeast.

Miscleavage at the presequence of rat preprolactin synthesized in pituitary cells incubated with a threonine analog.

Requirement for signal peptide cleavage of Escherichia coli prolipoprotein.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/0022-2836(84)90192-x

Article citations

Comprehensive Analysis of Signal Peptides in Saccharomyces cerevisiae Reveals Features for Efficient Secretion.

Processing of D1 Protein: A Mysterious Process Carried Out in Thylakoid Lumen.

In silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies.

Genome-Wide Identification and Bioinformatics Characterization of Superoxide Dismutases in the Desiccation-Tolerant Cyanobacterium Chroococcidiopsis sp. CCMEE 029.

Design of an improved universal signal peptide based on the α-factor mating secretion signal for enzyme production in yeast.

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