Occurrence of alpha 2-8 linked polysialosyl units in a neural cell adhesion molecule.

Finne J; Finne U; Deagostini-Bazin H; Goridis C

doi:10.1016/0006-291x(83)91490-0

Abstract

A brain cell surface protein (BSP-2) was isolated from mice of different ages by affinity chromatography using a monoclonal antibody. Analysis of glycopeptides obtained after pronase digestion revealed that the embryonal and neonatal forms of the antigen contained an unusually high proportion of sialic acid, which decreased during development. Methylation analysis of native and neuraminidase treated glycopeptides indicated that the sialic acid occurred as alpha 2-8 bound polysialosyl units, similar to those of the recently described developmentally regulated polysialosyl glycopeptides of rat brain. Furthermore, the carbohydrate and amino acid composition, and electrophoretic mobility of BSP-2 antigen correspond to those reported for a neural cell adhesion molecule (N-CAM).

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GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

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Occurrence of alpha 2-8 linked polysialosyl units in a neural cell adhesion molecule.

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The possible role of glycoproteins in neural function.

Title not supplied

Title not supplied

Occurrence of unique polysialosyl carbohydrate units in glycoproteins of developing brain.

Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide.

Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.

Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

A simple technique for eliminating interference by detergents in the Lowry method of protein determination.

A dot-immunobinding assay for monoclonal and other antibodies.

Preparation and fractionation of glycopeptides.

Citations & impact

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Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/0006-291x(83)91490-0

Article citations

Carbohydrate based biomaterials for neural interface applications.

Improved methods to characterize the length and quantity of highly unstable PolySialic acids subject category: (Carbohydrates, chromatographic techniques).

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.

Heparan Sulfate Is a Cellular Receptor for Enteric Human Adenoviruses.

MMP-9 Signaling Pathways That Engage Rho GTPases in Brain Plasticity.

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