Vascular changes in the brain of spontaneously hypertensive rats: hyaline and fibrinoid degeneration.

Amano S

doi:10.1002/path.1711210209

Abstract

The arterial changes designated as "hyalinosis" in the vessels of spontaneously hypertensive rats were studied using light- and electron-microscopy. Such changes were classified into three types, hyaline, fibrinoid and atypical fibrinoid degeneration. Hyaline material consisted mainly of excessive lamellar thickening of the basement membrane synthesised by endothelial and smooth muscle cells and associated with cellular debris and electron-dense particles. Acid mucopolysaccharides were found to be one of the components of the hyaline material. The nature of fibrinoid material was primarily fibrin derived from polymerised fibrinogen which has permeated through the injured endothelial cell layer. Atypical fibrinoid material consisted of granular and fibrillar substances derived from blood plasma. In some cases, all three changes were encountered in the same artery.

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Vascular changes in the brain of spontaneously hypertensive rats: hyaline and fibrinoid degeneration.

Abstract

Full text links

References

Proceedings: Electron microscopic study of vascular changes in SHR.

Title not supplied

1969 The hypertensive vascular crisis. An experimental study, Heinemann, London, p. 51.

Title not supplied

Paracrystalline forms of fibrinogen.

Sites of mucopolysaccharide synthesis in the lesions of experimental hypertension in rats.

Sulphate utilisation and mucopolysaccharide synthesis by the mesenteric arteries of rats with experimental hypertension.

TRITIATED THYMIDINE UPTAKE IN RAT HYPERTENSION.

The pathogenesis of hyaline arteriolosclerosis.

Hypertensive fibrinoid arteritis of the brain and gross cerebral hemorrhage: a form of "hyalinosis".

Citations & impact

Impact metrics

Citations of article over time

Article citations

Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats.

Dietary protein, but not carbohydrate, is a primary determinant of the onset of stroke in stroke-prone spontaneously hypertensive rats.

Fibrinoid necrosis of small brain arteries and arterioles and miliary aneurysms as causes of hypertensive hemorrhage: a critical reappraisal.

Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats.

Pathologic evidence of microvascular rarefaction in the brain of renal hypertensive rats.

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