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Integration of MAP kinase signal transduction pathways at the serum response element.

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Affiliations

  • 1. Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA.
      Authors
    • Whitmarsh AJ 1
    (1 author)

ORCIDs linked to this article

Science, 01 Jul 1995, 269(5222):403-407
https://doi.org/10.1126/science.7618106 PMID: 7618106 

Abstract 

The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK after treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli.

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