Defensins.

Ganz T; Lehrer RI

doi:10.1016/0163-7258(94)00076-f

Defensins.

Ganz T ¹,

Lehrer RI

Affiliations

1. Department of Medicine, University of California School of Medicine, Los Angeles 90024-1736, USA.
Authors
Ganz T¹
(1 author)

ORCIDs linked to this article

Ganz T | 0000-0002-2830-5469

Pharmacology & Therapeutics, 01 May 1995, 66(2):191-205
https://doi.org/10.1016/0163-7258(94)00076-f PMID: 7667395

Review

Abstract

Defensins are a family of small cationic, antibiotic peptides that contain six cysteines in disulfide linkage. The peptides are abundant in phagocytes and small intestinal mucosa of humans and other mammals and in the hemolymph of insects. They contribute to host defense against microbes and may participate in tissue inflammation and endocrine regulation during infection. Bioengineered defensins are potentially useful as prophylactic and therapeutic agents in infections.

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References

Articles referenced by this article (126)

Antimicrobial activity of rabbit leukocyte defensins against Treponema pallidum subsp. pallidum.
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Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.
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https://en.wikipedia.org/wiki/Beta_defensin_1

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Diseases in OMIM (2)

DEFENSIN, ALPHA, 1; DEFA1(OMIM - 125220)
DEFENSIN, BETA, 1; DEFB1(OMIM - 602056)

Search life-sciences literature (45,103,589 articles, preprints and more)

Defensins.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Antimicrobial activity of rabbit leukocyte defensins against Treponema pallidum subsp. pallidum.

Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections. Detection by immunoperoxidase staining for lactoferrin and cytochemical electron microscopy.

In vitro antimicrobial activity of defensins against ocular pathogens.

Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family.

The structure of the rabbit macrophage defensin genes and their organ-specific expression.

The propiece of human preprodefensin is required for efficient defensin production, processing and subcellular targeting

Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity

Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare.

A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin.

The inducible antibacterial peptides of dipteran insects.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/0163-7258(94)00076-f

Article citations

mthl1, a potential Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies.

Comprehensive analysis of alfa defensin expression and prognosis in human colorectal cancer.

Antimicrobial peptides from freshwater invertebrate species: potential for future applications.

Human Umbilical Cord Mesenchymal Stem Cells Prevent Bacterial Biofilm Formation.

Antibacterial Peptides Resistance in Staphylococcus aureus: Various Mechanisms and the Association with Pathogenicity.

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Wikipedia

Data

Data that cites the article

Diseases in OMIM (2)

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Search life-sciences literature (45,103,589 articles, preprints and more)

Defensins.

Author information

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

The propiece of human preprodefensin is required for efficient defensin production, processing and subcellular targeting

Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Other citations

Wikipedia

Data

Data that cites the article

Diseases in OMIM (2)

Similar Articles

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