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Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.

Author information

Affiliations

  • 1. Department of Molecular and Cell Biology, University of California, Berkeley 94720.
      Authors
    • Townsend SE 1
    (1 author)

Science, 01 Jan 1993, 259(5093):368-370
https://doi.org/10.1126/science.7678351 PMID: 7678351 

A comment on this article appears in "A stimulating new approach to cancer treatment." Science. 1993 Jan 15;259(5093):310-1.

Abstract 

A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8+ T cells; CD4+ T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.

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Read article at publisher's site: https://doi.org/10.1126/science.7678351

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Funding 

Funders who supported this work.

NCI NIH HHS (1)