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Antibody-dependent enhancement of infection and the pathogenesis of viral disease.

Author information

Affiliations

  • 1. Department of Tropical Medicine, University of Hawaii School of Medicine, Honolulu.
      Authors
    • Morens DM 1
    (1 author)

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 01 Sep 1994, 19(3):500-512
https://doi.org/10.1093/clinids/19.3.500 PMID: 7811870 

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Abstract 

Antibody-dependent enhancement of infection (ADE) is an in vitro serological phenomenon--or a group of phenomena--in which viral infection of susceptible cells is modified by the addition of virus-reactive antibody. Evidence suggests that ADE reflects immunologic processes that occur in vivo. Various severe and even fatal viral conditions of humans and animals, including dengue shock syndrome, the "early-death phenomenon" in experimental infections of immune animals, and other vaccine- and immunoglobulin-modified conditions, have been attributed to ADE by some researchers. ADE has caused great concern in relation to the development of vaccines against dengue virus and human immunodeficiency virus. More data are urgently needed on the mechanisms and determinants of ADE and on its alleged role in disease pathogenesis and in vaccine-associated phenomena.

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Read article at publisher's site: https://doi.org/10.1093/clinids/19.3.500

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Funding 

Funders who supported this work.

NCRR NIH HHS (1)