Development of a mouse model of Helicobacter pylori infection that mimics human disease.

Marchetti M; Aricò B; Burroni D; Figura N; Rappuoli R; Ghiara P

doi:10.1126/science.7886456

Development of a mouse model of Helicobacter pylori infection that mimics human disease.

Affiliations

1. Immunobiological Research Institute Siena (IRIS), Biocine SpA, Italy.
Authors
Marchetti M¹
(1 author)

Science, 01 Mar 1995, 267(5204):1655-1658
https://doi.org/10.1126/science.7886456 PMID: 7886456

A comment on this article appears in "The new path to preventing ulcers." Science. 1995 Mar 17;267(5204):1621-2.

Abstract

The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected mice from bacterial infection. This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans.

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References

Articles referenced by this article (24)

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Development of a mouse model of Helicobacter pylori infection that mimics human disease.

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Authors

Abstract

Full text links

References

Title not supplied

Inability of human clinical strains of Helicobacter pylori to colonize the alimentary tract of germfree rodents.

Title not supplied

Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.

Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology.

Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.

Title not supplied

Evaluation of two monkey species (Macaca mulatta and Macaca fascicularis) as possible models for human Helicobacter pylori disease.

Recombinant antigens prepared from the urease subunits of Helicobacter spp.: evidence of protection in a mouse model of gastric infection.

Morphological evidence of Campylobacter pylori pathogenicity in chronic gastritis and peptic ulcer.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1126/science.7886456

Article citations

Restoration of mitochondrial structure and function within Helicobacter pylori VacA intoxicated cells.

Ellagitannins from Castanea sativa Mill. Leaf Extracts Impair H. pylori Viability and Infection-Induced Inflammation in Human Gastric Epithelial Cells.

A Mouse Model of Ulcerative Cutaneous Leishmaniasis by Leishmania (Viannia) panamensis to Investigate Infection, Pathogenesis, Immunity, and Therapeutics.

Emerging Methods in Modeling Brain Development and Disease with Human Pluripotent Stem Cells.

Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease.

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Mouse Genome Informatics (MGI)

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Development of a mouse model of Helicobacter pylori infection that mimics human disease.

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