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Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.

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Affiliations

  • 1. Biogen Incorporated 14 Cambridge Center, Massachusetts 02142.
      Authors
    • Browning JL 1
    (1 author)

ORCIDs linked to this article

Cell, 01 Mar 1993, 72(6):847-856
https://doi.org/10.1016/0092-8674(93)90574-a PMID: 7916655 

Abstract 

The lymphokine tumor necrosis factor (TNF) has a well-defined role as an inducer of inflammatory responses; however, the function of the structurally related molecule lymphotoxin (LT alpha) is unknown. LT alpha is present on the surface of activated T, B, and LAK cells as a complex with a 33 kd glycoprotein, and cloning of the cDNA encoding the associated protein, called lymphotoxin beta (LT beta), revealed it to be a type II membrane protein with significant homology to TNF, LT alpha, and the ligand for the CD40 receptor. The gene for LT beta was found next to the TNF-LT locus in the major histocompatibility complex (MHC), a region of the MHC with possible linkage to autoimmune disease. These observations raise the possibility that a surface LT alpha-LT beta complex may have a specific role in immune regulation distinct from the functions ascribed to TNF.

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Read article at publisher's site: https://doi.org/10.1016/0092-8674(93)90574-a

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