Abstract
Objective
To determine whether clonally expanded B cells are present in the early infiltrates of minor labial salivary glands (LSG) of Sjögren's syndrome (SS) patients.Methods
Available paraffin-embedded LSG biopsies from 14 patients with primary SS were studied. DNA from LSG tissue was amplified by a polymerase chain reaction directed toward rearranged immunoglobulin gene DNA.Results
All LSG specimens showed oligoclonal or monoclonal B cell expansion. In one patient with plasma cell neoplasm, tumor and LSG specimens obtained at the same operation displayed different immunoglobulin gene rearrangements.Conclusion
Clonal expansion is characteristic of primary SS, and it is uniformly found in the early LSG infiltrates of patients who do not experience further progression to pseudolymphoma or lymphoma (mean followup 4.1 years after biopsy). This feature, together with the clonal discordance between the LSG and the B cell neoplasm found in one patient, suggests that additional steps are critical for the progression to malignancy.References
Articles referenced by this article (26)
Sjogren's syndrome (Sicca syndrome): current issues.
Ann Intern Med, (2 Pt 1):212-226 1980
MED: 7352730
Title not supplied
Clin Exp Immunol 1971
Development of malignant lymphoma in myoepithelial sialadenitis (Sjogren's syndrome).
Virchows Arch A Pathol Anat Histol, (1):11-43 1982
MED: 7043890
Nodal and extranodal lymphoproliferative disorders in Sjogren's syndrome: a clinical and immunopathologic study.
Hum Pathol, (5):482-492 1990
MED: 2110929
Demonstration and identification of monoclonal proteins in the urine of patients with Sjogren's syndrome.
Ann Rheum Dis, (2):109-112 1985
MED: 3919659
Urinary monoclonal free light chains in primary Sjogren's syndrome: an aid to the diagnosis of malignant lymphoma.
Ann Rheum Dis, (3):210-219 1986
MED: 3082300
The natural history of benign lymphoepithelial lesion of the salivary gland in which there is a monoclonal population of B cells. A report of two cases.
Am J Surg Pathol, (1):59-65 1991
MED: 1898682
Uniform detection of immunoglobulin-gene rearrangement in benign lymphoepithelial lesions.
N Engl J Med, (18):1118-1121 1987
MED: 3106808
Detection of clonally expanded salivary gland lymphocytes in Sjogren's syndrome.
Arthritis Rheum, (7):859-869 1989
MED: 2546568
Show 10 more references (10 of 26)
Citations & impact
Impact metrics
Citations of article over time
Article citations
Two cases of pseudolymphoma on the lips.
Br J Dermatol, 170(5):1204-1206, 01 May 2014
Cited by: 0 articles | PMID: 24428492
Sjögren's syndrome.
Annu Rev Pathol, 9:273-285, 18 Sep 2013
Cited by: 116 articles | PMID: 24050623
Review
Are the B cells cast with the leading part in the Sjogren's syndrome scenario?
Oral Dis, 20(6):529-537, 10 Jul 2013
Cited by: 9 articles | PMID: 23837848
Review
CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis.
Autoimmune Dis, 2012:189096, 24 Jan 2012
Cited by: 86 articles | PMID: 22312480 | PMCID: PMC3270541
Review
Free full text in Europe PMCPossible Mechanisms of Lymphoma Development in Sjögren's Syndrome.
Curr Immunol Rev, 9(1):13-22, 01 Feb 2013
Cited by: 27 articles | PMID: 23853604 | PMCID: PMC3706954
Go to all (22) article citations
Similar Articles
To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.
Immunoglobulin gene rearrangements in lymphoplasmacytic infiltrates of labial salivary glands in Sjögren's syndrome. A possible predictor of lymphoma development.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 79(6):723-729, 01 Jun 1995
Cited by: 31 articles | PMID: 7621030
Analysis of B-cell clonality in the hepatic tissue of patients with Sjögren's syndrome.
Scand J Rheumatol, 32(5):268-272, 01 Jan 2003
Cited by: 9 articles | PMID: 14690138
High prevalence of B-cell monoclonality in labial gland biopsies of Japanese Sjögren's syndrome patients.
Int J Hematol, 64(1):47-52, 01 Jul 1996
Cited by: 11 articles | PMID: 8757967
Labial salivary gland biopsy in Sjögren's syndrome.
Neth J Med, 40(3-4):148-157, 01 Apr 1992
Cited by: 3 articles | PMID: 1603205
Review
