Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Structure/function studies of lin-12/Notch proteins.

Author information

Affiliations

  • 1. Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
      Authors
    • Greenwald I 1
    (1 author)

Current Opinion in Genetics & Development, 01 Aug 1994, 4(4):556-562
https://doi.org/10.1016/0959-437x(94)90072-b PMID: 7950324 

Review

Abstract 

The lin-12/Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Recent structure/function studies have shown that the lin-12/Notch intracellular domain alone has the intrinsic signal-transducing activity of the intact protein, and that the role of the extracellular domain is to regulate this intrinsic activity. These studies have also suggested that the different lin-12/Notch proteins in a given organism are interchangeable biochemically and have addressed the role of lin-12/Notch genes in development.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/0959-437x(94)90072-b

References 

Articles referenced by this article (54)

Show 10 more references (10 of 54)

Citations & impact 

Impact metrics

63
Citations
Jump to Citations
12
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/41979712
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/41979712

Article citations

Go to all (63) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.