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Functional role of type I and type II interferons in antiviral defense.

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Affiliations

  • 1. Institute of Molecular Biology I, University of Zürich, Switzerland.
      Authors
    • Müller U 1
    (1 author)

Science, 01 Jun 1994, 264(5167):1918-1921
https://doi.org/10.1126/science.8009221 PMID: 8009221 

Abstract 

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

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Read article at publisher's site: https://doi.org/10.1126/science.8009221

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