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Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.

Author information

Affiliations

  • 1. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
      Authors
    • Borén T 1
    (1 author)

Science, 01 Dec 1993, 262(5141):1892-1895
https://doi.org/10.1126/science.8018146 PMID: 8018146 

A comment on this article appears in "Blood type and the risk of gastric disease." Science. 1994 Jun 3;264(5164):1386-8. A comment on this article appears in "New bind for ulcer bacterium." Science. 1993 Dec 17;262(5141):1817.

Abstract 

Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Leb antigen or antibodies to the Leb antigen inhibited bacterial binding. Gastric tissue lacking Leb expression did not bind H. pylori. Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.

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Read article at publisher's site: https://doi.org/10.1126/science.8018146

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Funding 

Funders who supported this work.

FIC NIH HHS (1)